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临床试验/NCT06959446
NCT06959446已完成不适用

Association Between Perioperative Homocysteine and Postoperative Complications/All-Cause Mortality in Elderly Patients Undergoing Non-Cardiac Surgery

Chinese PLA General Hospital0 个研究点目标入组 29,156 人开始时间: 2014年1月1日最近更新:

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
29,156
主要终点
Acute kidney injury (AKI)

研究概览

简要总结

This study aims to explore the association between perioperative homocysteine (Hcy) levels and their pre-to-postoperative changes with postoperative complications and all-cause mortality in elderly patients undergoing non-cardiac surgery. Besides, the dynamic changes in Hcy levels may reflect metabolic shifts, highlighting their potential value in predicting adverse postoperative outcomes. These findings suggest that monitoring perioperative Hcy levels and their changes could help identify high-risk patients and inform postoperative management strategies.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Retrospective

入排标准

年龄范围
65 Years 至 —(Older Adult)
性别
All
接受健康志愿者

入选标准

  • Hospitalized older (≥ 65 years) patients underwent non-cardiac surgery

排除标准

  • Without preoperative Hcy data (n= 44115)
  • Neurosurgery (n= 3343)
  • Kidney or renal artery surgery (n= 2478)
  • Chronic kidney disease (n=577)

结局指标

主要结局

Acute kidney injury (AKI)

时间窗: January 2014 - August 2019

次要结局

  • mortality(January 2014 - August 2020)

研究者

发起方
Chinese PLA General Hospital
申办方类型
Other
责任方
Principal Investigator
主要研究者

Jingsheng Lou

Professor

Chinese PLA General Hospital

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