A Clinical Trial to Compare Lasotronix Alone or in Combination With CPP-ACP to Treat DH
- Conditions
- Cervical LesionDentin SensitivityHypersensitivity
- Interventions
- Device: Experimental groupBehavioral: Control groupOther: Active comparatorCombination Product: Combination of laser and paste
- Registration Number
- NCT06463938
- Lead Sponsor
- Dow University of Health Sciences
- Brief Summary
Dentin hypersensitivity (DH) is defined as sharp pain of a shorter duration arise from exposed dentin in response to several chemicals and thermal or tactile stimuli that cannot be ascribed to other dental defects". DH has a prevalence rate ranging from 1.3% to 92.1%, commonly affecting old ages. The use of laser has opened new dimensions in the treatment of DH. To the author's knowledge, not much research work has been conducted using LASOTRONIX as a treatment modality with CPP-ACP. Therefore, this research aims to determine the effectiveness of Casein phospho peptide paste (CPP-ACP) used alone or combined with a diode laser (LASOTRONIX).
- Detailed Description
DH has a prevalence rate ranging from 1.3% to 92.1%, commonly affecting old ages, and the frequency of DH in patients suffering from periodontal disease is 3-57%. Pakistan has reported prevalence from different cities, with 36.4% from Karachi and 22% from Lahore.
The use of laser has opened new dimensions in the treatment of DH. Theories that support laser therapy explain that irradiation blocks the pain in dentinal tubules by melting and recrystallization of dentin or by tertiary dentine production or evaporation of dentinal fluid. Considering the oral soft tissues which contain high amounts of water, Lasotronix SMARTm laser diodes have been carefully designed to show their high transmission. The 635nm wavelength is optimal for activating tolonium chloride dye for photo-activated chemo therapy, eliminating all bacteria and biofilms without any side effects. 200 mW power provides safe cold bio stimulation and photo disinfection within a reasonably short therapy time. Application of Sodium fluoride (NaF) has also been indicated for hypersensitivity pains. Its application in the form of gel occludes the tubule by calcium fluoride precipitation. Agents like potassium nitrate also have promising effects, which increase the concentration of potassium ions in nerve endings and alter the nerve action potential in conducting the sensory stimuli.
Recently DH treatment has been conducted with different types of laser with different wavelengths, either alone or in combination with desensitizing agents and varnishes and has revealed effective results. To the author's knowledge, not much research work has been conducted using LASOTRONIX as a treatment modality with CPP-ACP. Therefore, this research aims to determine the effectiveness of Casein phospho peptide paste (CPP-ACP) used alone or combined with a diode laser (LASOTRONIX).
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 120
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Experimental Experimental group would consist of patients (n=30) who will be given diode laser therapy only Control Control group would be a control group Active Comparator Active comparator would include patients (n=30) who will be given CPP-ACP paste application only Combination Combination of laser and paste would include patients (n=30) who will be given a combination of CPP-ACP paste \& Laser therapy.
- Primary Outcome Measures
Name Time Method treatment of dentin hypersensitivity 0-3 moths VAS Visual analogue scale will be used to determine the efficacy of different treatment methods.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Dr Sanam Faheem
🇵🇰Karachi, Sindh, Pakistan