Effects of sitagliptin on gastric emptying in healthy subjects.

Phase 1

• Conditions: Gastric emptying; Oral and Gastrointestinal - Normal oral and gastrointestinal development and function

• Registration Number: ACTRN12607000378426
• Lead Sponsor: Royal Adelaide Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2007-07-18
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

Body Mass Index (BMI) 19-25 kg/m2

Exclusion Criteria

GI diseaseAlcohol >20g dailyCigarettes >10 per dayPregnant or lactating femalesMedication known to influence GI functionCalculated Creatinine Clearance <60ml/minSubjects exposed to ionising radiation in previous 12 months.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Gastric emptying rate[At 15 minute intervals from 0 - 150 minutes, 30 minutes intervals from 150 - 240 minutes.];GLP-1 levels[At -2 minutes, 15 minute intervals from 0 - 120 minutes, 30 minute intervals from 120 - 240 minutes.]

Secondary Outcome Measures

Name	Time	Method
Intragastric Distribution [15 min intervals from 0 - 150 mins, 30 min intervals from 150 - 240 mins];Glycaemia, Insulinaemia and Gastro Intestinal (GI) Hormones[-2 mins, 15 minute intervals from 0 - 120 mins, 30 min intervals from 120 - 240 mins];Appetite[-2 mins, 15 minute intervals from 0 - 120 mins, 30 min intervals from 120 - 240 mins]