A study to investigate the effect of Nagapheni (Optunia elatior Mill.) in the treatment of anemia.

Completed

• Conditions: Patients selected on the basis of the classical symptoms of Pandu(anaemia) and Level of Hb is low to normal value

• Registration Number: CTRI/2015/02/005547
• Lead Sponsor: Institute for post gradute teaching and research in Ayurevda gujarat ayurveda university jamnagar

Brief Summary

Present open labelled, randomised clinical trial was planned to evaluate the efficacy of the *Nagaphani* fruit *Swarasa* (*Opuntia* *elatior* Mill.) in the management of *Pandu* (anaemia). Well known drug, *Punarnava Mandura* was taken as comparator drug as it is experimentally as well as clinically proved effective drug for *Pandu*. Total 105 patients were registered and randomly divided into two groups. In group A *Nagaphani Swarasa* was administrated at a dose of 20ml twice a day withluke warm water before meal while group B received *Punarnava Mandura* at a dose of 500mg two tablet twice a day with *Takra* before meal forthe duration of 2 months with 1 month follow up. At the end of the trial both drugs were found effective in the management of *Pandu* by significantly significant (p<0.001) relieving in all the cardinal symptoms of *Pandu*. Both groups produced statistically significant increase in Hb%, TRBC and Serum Iron. In TIBC, group A shows statistically significant result (p>0.05) while group B produced statistically insignificant result (p>0.05). But the difference in between is insignificant. No adverse reactions were reported during the clinical trial indicating safety of *Nagaphani Swarasa.* Thus, alternative hypothesis is accepted stating that *Nagaphani* (*Opuntia elatior* Mill.) fruit can be used in the treatment of *Pandu*.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-06-02
• Last Update Posted: 2016-02-12

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Patients between age of 18-60 yrs Irrespective of sex Diagnosed Pandu as per with classical symptomsHb% below 12gm (F) and below 13gm (M) or reduced RBC count.

Exclusion Criteria

Age less than 18 years and more than 60 years Pregnancy and lactation Severe Renal Hepatic Cardiac disease Cancer Any continuing blood loss e g Hematemesis Melaena Bleeding piles etc.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
relief in the of symptoms on Pandu(anaemia)like Panduta (Pallor, Panduta (Pallor)etc.	Hemoglobin will be estimated after 2 month of trial drug Opuntia elatior Mill.

Secondary Outcome Measures

Name	Time	Method
relief in Shrama (Fatigue), Shwasa (Exertional Dyspnoea) etc.	upto present study

Trial Locations

Locations (1)

IPGT AND RA JAMNAGAR; 🇮🇳 Jamnagar, GUJARAT, India

IPGT AND RA JAMNAGAR

🇮🇳Jamnagar, GUJARAT, India

Shashikant Prajapati

Principal investigator

9428563834

dr.shashi_ayu@yahoo.com