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Clinical Trials/NCT00710255
NCT00710255CompletedNot Applicable

Role of Leukotrienes and Adenosine in Hyperpnea-induced Bronchospasm Determined by Dynamic Analysis of Exhaled Breath Condensate.

University of Vermont1 site in 1 country8 target enrollmentStarted: October 2007Last updated:
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Conditions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Enrollment
8
Locations
1
Primary Endpoint
Change in level of cystLTs and adenosine
Study OverviewStudy DesignEligibility CriteriaOutcomesInvestigatorsSitesRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

This research is being conducted to help us better understand what causes exercise induced asthma. The investigators hypothesize that two types of chemicals, cysteinyl leukotrienes and adenosine, play an important role. The investigators will be measuring these chemicals in the exhaled breath of volunteers with exercise induced asthma as they undergo a test to mimic exercise induced asthma. The investigators will determine how the levels of these chemicals change in association with how lung function changes before, during and after an episode of exercise induced asthma.

Study Design

Study Type
Observational
Observational Model
Cohort
Time Perspective
Prospective

Eligibility Criteria

Ages
12 Years to 75 Years (Child, Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • •Physician diagnosed asthma
  • •Age 12-75 yrs
  • •FEV1 > 70% predicted
  • •HIB response > 10 %
  • •No smoking last 6 mo and < 10 pack yrs
  • •No URI last 4 weeks
  • •No asthma exacerbation last 4 weks
  • •Able to withhold SABA > 8 hrs and LABA > 24 hrs

Exclusion Criteria

  • •Other lung disease
  • •Cardiac disease or other condition that would preclude safe participation, on theophylline or leukotriene modifiers

Outcomes

Primary Outcomes

Change in level of cystLTs and adenosine

Time Frame: Before and after hyperpnea challenge

Secondary Outcomes

  • Change in pH of EBC and change in pulmonary function(Before and after hyperpnea challenge)

Investigators

Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

David Kaminsky, MD

Professor

University of Vermont

Study Sites (1)

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