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Clinical Trials/NCT00710255
NCT00710255
Completed
Not Applicable

Role of Leukotrienes and Adenosine in Hyperpnea-induced Bronchospasm Determined by Dynamic Analysis of Exhaled Breath Condensate.

University of Vermont1 site in 1 country8 target enrollmentOctober 2007
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ConditionsAsthma, Exercise Induced

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Asthma, Exercise Induced
Sponsor
University of Vermont
Enrollment
8
Locations
1
Primary Endpoint
Change in level of cystLTs and adenosine
Status
Completed
Last Updated
9 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSitesSimilar Trials

Overview

Brief Summary

This research is being conducted to help us better understand what causes exercise induced asthma. The investigators hypothesize that two types of chemicals, cysteinyl leukotrienes and adenosine, play an important role. The investigators will be measuring these chemicals in the exhaled breath of volunteers with exercise induced asthma as they undergo a test to mimic exercise induced asthma. The investigators will determine how the levels of these chemicals change in association with how lung function changes before, during and after an episode of exercise induced asthma.

Registry
clinicaltrials.gov
Start Date
October 2007
End Date
July 2009
Last Updated
9 years ago
Study Type
Observational
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

David Kaminsky, MD

Professor

University of Vermont

Eligibility Criteria

Inclusion Criteria

  • •Physician diagnosed asthma
  • •Age 12-75 yrs
  • •FEV1 \> 70% predicted
  • •HIB response \> 10 %
  • •No smoking last 6 mo and \< 10 pack yrs
  • •No URI last 4 weeks
  • •No asthma exacerbation last 4 weks
  • •Able to withhold SABA \> 8 hrs and LABA \> 24 hrs

Exclusion Criteria

  • •Other lung disease
  • •Cardiac disease or other condition that would preclude safe participation, on theophylline or leukotriene modifiers

Outcomes

Primary Outcomes

Change in level of cystLTs and adenosine

Time Frame: Before and after hyperpnea challenge

Secondary Outcomes

  • Change in pH of EBC and change in pulmonary function(Before and after hyperpnea challenge)

Study Sites (1)

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