Role of Leukotrienes and Adenosine in Hyperpnea-induced Bronchospasm
Completed
- Conditions
- Asthma, Exercise Induced
- Interventions
- Procedure: Hyperpnea challenge
- Registration Number
- NCT00710255
- Lead Sponsor
- University of Vermont
- Brief Summary
This research is being conducted to help us better understand what causes exercise induced asthma. The investigators hypothesize that two types of chemicals, cysteinyl leukotrienes and adenosine, play an important role. The investigators will be measuring these chemicals in the exhaled breath of volunteers with exercise induced asthma as they undergo a test to mimic exercise induced asthma. The investigators will determine how the levels of these chemicals change in association with how lung function changes before, during and after an episode of exercise induced asthma.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 8
Inclusion Criteria
- Physician diagnosed asthma
- Age 12-75 yrs
- FEV1 > 70% predicted
- HIB response > 10 %
- No smoking last 6 mo and < 10 pack yrs
- No URI last 4 weeks
- No asthma exacerbation last 4 weks
- Able to withhold SABA > 8 hrs and LABA > 24 hrs
Read More
Exclusion Criteria
- Other lung disease
- Cardiac disease or other condition that would preclude safe participation, on theophylline or leukotriene modifiers
Read More
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Asthmatics Hyperpnea challenge Asthmatics with exercise induced bronchospasm
- Primary Outcome Measures
Name Time Method Change in level of cystLTs and adenosine Before and after hyperpnea challenge
- Secondary Outcome Measures
Name Time Method Change in pH of EBC and change in pulmonary function Before and after hyperpnea challenge
Trial Locations
- Locations (1)
Vermont Lung Center
🇺🇸Colchester, Vermont, United States