Observational Study of Choline, Its Metabolites, and Phospholipids in Preterm Infants
Completed
- Conditions
- Prematurity
- Registration Number
- NCT02027584
- Lead Sponsor
- University Hospital Tuebingen
- Brief Summary
To study concentrations of choline, its metabolites, and phospholipids in cord blood and remnants of clinically indicated blood samples
- Detailed Description
To collect cord plasma in preterm and term infants. To collect remnants of clinically indicated blood samples in parturients and hospitalized preterm infants during neonatal intensive care.
To determine concentrations of choline, its metabolites, and phospholipids by mass spectrometry.
To compare cord plasma concentrations with postnatal plasma concentrations.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 414
Inclusion Criteria
- meeting criteria of the 4 cohorts
Exclusion Criteria
- none pre-defined
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Concentration of choline in plasma at times when a clinically indicated blood sample is taken before discharge home from the initial neonatal hospitalization (at a postnatal age of up to 4-5 months at the most in very preterm infants)
- Secondary Outcome Measures
Name Time Method Concentrations of molecular species of phosphatidylcholine and phosphatidylethanolamine at times when a clinically indicated blood sample is taken before discharge home from the initial neonatal hospitalization (at a postnatal age of up to 4-5 months at the most in very preterm infants) concentrations of choline metabolites at times when a clinically indicated blood sample is taken before discharge home from the initial neonatal hospitalization (at a postnatal age of up to 4-5 months at the most in very preterm infants)
Trial Locations
- Locations (1)
University Hospital Tuebingen
🇩🇪Tuebingen, Germany
University Hospital Tuebingen🇩🇪Tuebingen, Germany