Supply of Term and Preterm Neonates With Choline, Lipids and Vitamines

University Hospital Tuebingen1 site in 1 country414 target enrollmentNovember 2008

ConditionsPrematurity

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Prematurity
Sponsor: University Hospital Tuebingen
Enrollment: 414
Locations: 1
Primary Endpoint: Concentration of choline in plasma
Status: Completed
Last Updated: 12 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

To study concentrations of choline, its metabolites, and phospholipids in cord blood and remnants of clinically indicated blood samples

Detailed Description

To collect cord plasma in preterm and term infants. To collect remnants of clinically indicated blood samples in parturients and hospitalized preterm infants during neonatal intensive care. To determine concentrations of choline, its metabolites, and phospholipids by mass spectrometry. To compare cord plasma concentrations with postnatal plasma concentrations.

Registry

clinicaltrials.gov

Start Date

November 2008

End Date

July 2013

Last Updated

12 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

University Hospital Tuebingen

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•meeting criteria of the 4 cohorts

Exclusion Criteria

•none pre-defined

Outcomes

Primary Outcomes

Concentration of choline in plasma

Time Frame: at times when a clinically indicated blood sample is taken before discharge home from the initial neonatal hospitalization (at a postnatal age of up to 4-5 months at the most in very preterm infants)

Secondary Outcomes

Concentrations of molecular species of phosphatidylcholine and phosphatidylethanolamine(at times when a clinically indicated blood sample is taken before discharge home from the initial neonatal hospitalization (at a postnatal age of up to 4-5 months at the most in very preterm infants))
concentrations of choline metabolites(at times when a clinically indicated blood sample is taken before discharge home from the initial neonatal hospitalization (at a postnatal age of up to 4-5 months at the most in very preterm infants))