Rôle du Cervelet et de l'Aire Motrice supplémentaire Dans le contrôle Postural au Cours de la Marche Chez l'Homme
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- postural control during gait initiation
研究概览
简要总结
In human, the physiology of gait and balance is not clearly established. By using functional imaging and electrophysiological techniques, various brain regions from the cortex to the midbrain area, including the cerebellum, have been identified as involved in such control. The specific role of these structures in both the capacity to go forward (locomotion) and stand upright (balance), but also in the different phases of the gait initiation process, are not known, however. In this study,the investigators aimed to assess the specific role of both the supplementary motor area (SMA) and the cerebellum in postural control during the initiation of gait. For this purpose, the investigators plan to study the gait initiation in 20 healthy subjects before and after functional inactivation (using inhibitory repetitive transcranial magnetic stimulation, rTMS) of the cerebellum or SMA. Biomechanical, kinematic and electromyographic parameters of the gait initiation will be recorded using a force platform, reflective markers with infrared cameras (VICON system) and lower limbs surface EMG electrodes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 70 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18-70 years
- •agree to participate to the study with signature of the informed consent
- •heathy insurance
- •normal clinical exam
排除标准
- •previous medical history of neurological, rheumatological, orthopedic or psychiatric disorders
- •contra-indication to MRI or TMS
- •drug treatment that modifies the nervous central system excitability (antidepressant, antiepileptic, neuroleptic)
- •chronic alcoholism
结局指标
主要结局
postural control during gait initiation
时间窗: change between baseline and 5 minutes after transcranial magnetic stimulation
braking capacity
次要结局
- duration of anticipatory postural adjustments(change between baseline and 5 minutes after transcranial magnetic stimulation)
