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临床试验/NCT02976298
NCT02976298已完成1 期

Rôle du Cervelet et de l'Aire Motrice supplémentaire Dans le contrôle Postural au Cours de la Marche Chez l'Homme

Institut National de la Santé Et de la Recherche Médicale, France2 个研究点 分布在 1 个国家目标入组 20 人开始时间: 2013年2月1日最近更新:
适应症

试验速览

阶段
1 期
状态
已完成
发起方
入组人数
20
试验地点
2
主要终点
postural control during gait initiation

研究概览

简要总结

In human, the physiology of gait and balance is not clearly established. By using functional imaging and electrophysiological techniques, various brain regions from the cortex to the midbrain area, including the cerebellum, have been identified as involved in such control. The specific role of these structures in both the capacity to go forward (locomotion) and stand upright (balance), but also in the different phases of the gait initiation process, are not known, however. In this study,the investigators aimed to assess the specific role of both the supplementary motor area (SMA) and the cerebellum in postural control during the initiation of gait. For this purpose, the investigators plan to study the gait initiation in 20 healthy subjects before and after functional inactivation (using inhibitory repetitive transcranial magnetic stimulation, rTMS) of the cerebellum or SMA. Biomechanical, kinematic and electromyographic parameters of the gait initiation will be recorded using a force platform, reflective markers with infrared cameras (VICON system) and lower limbs surface EMG electrodes.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
主要目的
Basic Science
盲法
Double (Participant, Outcomes Assessor)

入排标准

年龄范围
18 Years 至 70 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • 18-70 years
  • agree to participate to the study with signature of the informed consent
  • heathy insurance
  • normal clinical exam

排除标准

  • previous medical history of neurological, rheumatological, orthopedic or psychiatric disorders
  • contra-indication to MRI or TMS
  • drug treatment that modifies the nervous central system excitability (antidepressant, antiepileptic, neuroleptic)
  • chronic alcoholism

结局指标

主要结局

postural control during gait initiation

时间窗: change between baseline and 5 minutes after transcranial magnetic stimulation

braking capacity

次要结局

  • duration of anticipatory postural adjustments(change between baseline and 5 minutes after transcranial magnetic stimulation)

研究者

发起方
Institut National de la Santé Et de la Recherche Médicale, France
申办方类型
Other Gov
责任方
Sponsor

研究点 (2)

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