BPF Genetics of ILD Study

Active, not recruiting

• Conditions: Lung; Disease, Interstitial, With Fibrosis; Alveolitis, Extrinsic Allergic; Bird Fancier's Lung; Lung Diseases, Interstitial; Idiopathic Pulmonary Fibrosis; Idiopathic Interstitial Pneumonias

• Registration Number: NCT03747627
• Lead Sponsor: University of Dundee

Brief Summary

The investigators aim to examine the genetic determinants of interstitial lung disease in a cohort of subjects with regular exposure to pigeons, a known cause of one form of interstitial lung disease known as hypersensitivity pneumonitis. In addition we will examine immunological causes for hypersensitivity pneumonitis in this group.

We anticipate our work will provide insights of use to clinicians and patients with hypersensitivity pneumonitis and other interstitial lung diseases.

Detailed Description

The investigators aim to recruit participants with regular racing pigeon exposure at national (UK) and regional pigeon fancier meetings.

Consenting subjects will complete questionnaires, provide blood samples for genetic analysis and immunological testing and undertake lung function measurements.

Subjects will be observed, and encouraged to report referral to specialist respiratory services, and following this information will be sought on diagnosis (including supporting evidence). Where interstitial lung disease is detected this will be linked to subsequent unbiased analysis to detect potential predisposing genetic associations.

Study Timeline

• Study First Submitted: 2018-11-14
• Study First Submitted QC: 2018-11-19
• Study First Posted: 2018-11-20
• Study Start: 2019-01-19
• Primary Completion: 2025-01-19
• Status Verified: 2025-04
• Last Update Submitted: 2025-04-22
• Last Update Posted: 2025-04-25
• Study Completion: 2028-01-01

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 475

Inclusion Criteria

• regular exposure to racing pigeons

Exclusion Criteria

• Unwilling to participate

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Relationship of specific genetic markers to development of interstitial lung disease	5 years	Participants will be screened for MUC5B genetic profile to allow examination of MUC5B genetic profile relationship with risk of developing interstitial lung disease in this group

Trial Locations

Locations (2)

Royal Pigeon Racing Association Meeting; 🇬🇧 Blackpool, United Kingdom

Scottish Homing Union; 🇬🇧 Lanark, United Kingdom