British Pigeon Fanciers Genetics of Interstitial Lung Disease Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 475
- 试验地点
- 4
- 主要终点
- Relationship of specific genetic markers to development of interstitial lung disease
研究概览
简要总结
The investigators aim to examine the genetic determinants of interstitial lung disease in a cohort of subjects with regular exposure to pigeons, a known cause of one form of interstitial lung disease known as hypersensitivity pneumonitis. In addition we will examine immunological causes for hypersensitivity pneumonitis in this group.
We anticipate our work will provide insights of use to clinicians and patients with hypersensitivity pneumonitis and other interstitial lung diseases.
详细描述
The investigators aim to recruit participants with regular racing pigeon exposure at national (UK) and regional pigeon fancier meetings.
Consenting subjects will complete questionnaires, provide blood samples for genetic analysis and immunological testing and undertake lung function measurements.
Subjects will be observed, and encouraged to report referral to specialist respiratory services, and following this information will be sought on diagnosis (including supporting evidence). Where interstitial lung disease is detected this will be linked to subsequent unbiased analysis to detect potential predisposing genetic associations.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •regular exposure to racing pigeons
排除标准
- •Unwilling to participate
结局指标
主要结局
Relationship of specific genetic markers to development of interstitial lung disease
时间窗: 5 years
Participants will be screened for MUC5B genetic profile to allow examination of MUC5B genetic profile relationship with risk of developing interstitial lung disease in this group
次要结局
未报告次要终点
研究者
Mark Spears
Dr Mark Spears, Consultant in Respiratory Medicine
University of Dundee