Ultrasound-Guided Sciatic Popliteal Nerve Block vs. Erector Spinae Plane Block in Endovascular Management of CLI

Completed

• Conditions: Critical Limb Ischemia (CLI); Popliteal Nerve Block; ESPB

• Registration Number: NCT06913348
• Lead Sponsor: Minia University Hospital

Brief Summary

Comparison of popliteal sciatic nerve block and erector spinae plane block (ESPB) in patients undergoing endovascular management of critical lower limb ischemia (CLI).

Detailed Description

Nerve blocks, particularly regional anesthesia techniques, have been increasingly used in the endovascular management of critical lower limb ischemia (CLI). These techniques offer numerous advantages over general and local anesthesia.

Primary Advantages of Nerve Blocks:

1. Superior Pain Control

Nerve blocks, such as femoral and sciatic nerve blocks, provide effective pain relief by anesthetizing the nerve supply to the lower limb.

They offer more comprehensive analgesia than local anesthesia alone, as they numb the entire area around the puncture site.

2. Enhanced Patient Comfort

Nerve blocks allow patients to remain pain-free during and after the procedure.

They minimize discomfort even in lengthy or complex cases.

3. Reduction in Systemic Analgesic Requirements

By providing localized anesthesia, nerve blocks significantly reduce the need for systemic analgesics, particularly opioids.

This is essential because CLI patients often have comorbidities that make opioid use risky.

4. Fewer Opioid-Related Side Effects

Nerve blocks reduce the incidence of opioid-related side effects, including nausea, vomiting, respiratory depression, and sedation.

5. Improved Hemodynamic Stability

Nerve blocks preserve autonomic nervous system function, reducing fluctuations in blood pressure and heart rate compared to general anesthesia.

This is especially beneficial for CLI patients, who frequently have underlying cardiovascular disease.

Study Timeline

• Study Start: 2024-03-20
• Primary Completion: 2024-10-20
• Study Completion: 2025-01-05
• Status Verified: 2025-03
• Study First Submitted: 2025-03-01
• Study First Submitted QC: 2025-03-29
• Last Update Submitted: 2025-03-29
• Study First Posted: 2025-04-06
• Last Update Posted: 2025-04-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

1. Patient age will be 20-70 years.
2. Patients will be diagnosed with critical lower limb ischemia by clinical presentations and investigations.
3. ASA physical status 2-3

Exclusion Criteria

1. Patient refusal to participate in this study.
2. Patient inability to understand the scales or to describe to the investigators.
3. Coagulation disorder.
4. Sever renal or kidney dysfunction.
5. Taking opioids before admission.
6. Morbid obesity .

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Block quality	Baseline (immediately after block administration).	Assessment of the occurrence of complete motor and sensory block.

Secondary Outcome Measures

Name	Time	Method
Postoperative Analgesia Duration	Up to 24 hours postoperatively.	Time from block administration to the first request for rescue analgesia.; .

Trial Locations

Locations (1)

Minia university hospital; 🇪🇬 Minia, Minia governorate, Egypt