Development of a scoring system to predict risk of death in exacerbations of chronic obstructive pulmonary disease (COPD) requiring assisted ventilation.
Not Applicable
Completed
- Conditions
- Chronic obstructive pulmonary disease (COPD).RespiratoryChronic obstructive pulmonary disease
- Registration Number
- ISRCTN16977236
- Lead Sponsor
- orthumbria Healthcare NHS Foundation Trust
- Brief Summary
2021 Results article in https://pubmed.ncbi.nlm.nih.gov/33479109/ (added 02/11/2022)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 489
Inclusion Criteria
1. Aged over 35 years
2. Smoking history greater than or equal to 10 pack years
3. Obstructive spirometry (FEV1/FVC < 0.7)
4. AECOPD primary diagnosis
5. Respiratory acidosis treated with NIV or IPPV (arterial blood gas pH <7.35, pCO2 > 6.0)
Exclusion Criteria
1. Previous inclusion in the study
2. Other illness likely to limit survival to less than 1 year
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <br> Prediction of in-hospital mortality within the derivation cohort, assessed by the area under the receiver operating characteristic (AUROC) curve for tools developed using:<br> 1. Indices available on admission<br> 2. All indices up to and including the time of deterioration<br>
- Secondary Outcome Measures
Name Time Method <br> 1. Comparison of the AUROC curves for both novel tools<br> 2. Comparison of the AUROC curves for both novel tools to CAPS and APACHE II<br> 3. 30 day, 90 day, 180 day and 1 year mortality<br> 4. 30 and 90 day readmission rates<br> 5. Comparison of outcomes in patients with, and without pre-defined characteristics:<br> 5.1. Late failure of NIV (recurrent respiratory acidaemia, despite on-going ventilatory support)<br> 5.2. Persistent hypercapnia<br> 5.3. Long-term oxygen therapy<br> 5.4. Long-term ventilation on discharge<br>