Study to Assess Efficacy and Safety of Cx601, Adult Allogeneic Expanded Adipose-derived Stem Cells (eASC) for the Treatment of Complex Perianal Fistula(s) in Participants With Crohn's Disease (CD)
- Registration Number
- NCT03279081
- Lead Sponsor
- Tigenix S.A.U.
- Brief Summary
The purpose of this study is to evaluate the combined remission of complex perianal fistulas, defined as the clinical assessment at Week 24 of closure of all treated external openings that were draining at baseline despite gentle finger compression, and absence of collections greater than (\>) 2 centimeter (cm) (in at least 2 dimensions) confirmed by blinded central magnetic resonance imaging (MRI) assessment at Week 24.
- Detailed Description
This study is to assess the efficacy and safety of Cx601, eASC, for the treatment of complex perianal fistulas in participants with Crohn's disease.
The study will randomize approximately 554 participants.
* Cx601 eASCs intralesional injection
* Placebo - Cx601 placebo-matching eASCs intralesional injection
Study treatments will be allocated, on a 1:1 ratio, by central randomization through interactive web response system (IWRS). The study will follow an add-on design, participants receiving any ongoing concomitant medical treatment, at stable doses at the time of screening, for the CD will be allowed to continue it throughout the study.
The primary efficacy analysis, will be conducted at Week 24 timepoint. The double blind design will be maintained up to Week 52 (both participant and investigator) by a specific blinding for study treatment administration and for evaluating its efficacy.
This multicenter trial will be conducted globally across 150 centers. The overall time to participate in this study is approximately 5 years.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 569
-
Signed informed consent.
-
Participants of either gender greater than or equal to (>=) 18 years and less than or equal to (<=) 75 years of age.
-
Participants with CD diagnosed at least 6 months prior to Screening visit in accordance with accepted clinical, endoscopic, histological and/or radiological criteria.
-
Presence of complex perianal fistula(s) with a maximum of 2 internal openings and a maximum of 3 external openings based on clinical assessment; a central reading of a locally performed contrast enhanced (gadolinium) pelvic MRI will be performed to confirm location of the fistula and potential associated perianal abscess(es). Fistula(s) must have been draining for at least 6 weeks prior to Screening visit. Actively draining simple subcutaneous fistula(s), at the time of Screening visit, are not allowed in this study. A complex perianal fistula is defined as a fistula that meets one or more of the following criteria :
- High inter-sphincteric, high trans-sphincteric, extra-sphincteric or suprasphincteric.
- Presence of >=2 external openings.
- Associated perianal abscess(es). Note: Abscesses that are larger than 2 cm at least 2 dimensions on MRI must be confirmed to have been drained adequately by the surgeon during the preparation curettage in order to be eligible.
-
Clinically controlled, nonactive or mildly active CD, during the last six months prior to Screening visit with:
-
A patient reported outcomes (PRO-2) score <14 at Screening, AND
-
A colonoscopy documenting the absence of ulcers larger than 0.5 cm in the colonic mucosa:
- If colonoscopy data are not available within 6 months prior to Screening:
-
A simple endoscopic score for Crohn's Disease (SES-CD) <=6 with absence of rectal ulcers larger than 0.5 cm must be documented in a colonoscopy performed at Screening before randomization.
- If colonoscopy data are available within 6 months prior to Screening, the following must be documented, otherwise a new colonoscopy (as above) will be mandatory:
-
The absence of ulcers larger than 0.5 cm in the colonic mucosa AND
-
the improvement or no worsening in abdominal pain and/or in the diarrhea, sustained for one week or more, since the last colonoscopy was performed in the clinical records until Screening visit.
AND
o No hemoglobin decrease >=2.0 gram per deciliter (g/dL) or an unexplained rising C-reactive protein (CRP), > 5.0 milligram per liter (mg/L) to a concentration above the referenced upper limit of normal (ULN) (unless the rise is due to a known process other than luminal Crohn's Disease), since the last colonoscopy was performed as compared to results during the Screening visit.
AND
o no initiation or intensification of treatment with corticosteroids, immunosuppressants or monoclonal antibodies (mAbs) dose regimen since the last endoscopy up to Screening visit.
-
-
Participants whose perianal fistulas were previously treated and have shown an inadequate response or a loss of response while they were receiving either an immunosuppressive agent or tumour necrosis factor (TNF)-alpha antagonist or vedolizumab or ustekinumab, or having documented intolerance to any of these treatments administered at least at approved or recommended doses during the minimum period mentioned:
- Immunosuppressive agents: at least 3 months treatment with azathioprine (2-3 milligram per kilogram per day [mg/kg/day]), 6-mercaptopurine (1-1.5 mg/kg/day), or subcutaneous/intramuscular methotrexate (25 mg/week) prior to Screening for the study.
- TNFalpha antagonists:
- Infliximab: at least 14 weeks treatment at the approved doses for induction and/or maintenance in Crohn´s disease prior to screening for the study. For induction: 1 intravenous dose of 5 milligram per kilogram (mg/kg) followed by the same dose 2 and 6 weeks after. For maintenance: 5-10 mg/kg intravenously every 8 weeks, or more frequently.
- Adalimumab: at least 14 weeks treatment at the approved doses for induction and/or maintenance in Crohn's disease prior to screening for the study. For induction: 1 subcutaneous dose of 160 milligram (mg), followed by 80 mg 2 weeks after. For maintenance: 40 mg subcutaneously every other week, or weekly.
- Certolizumab l: at least 14 weeks treatment at the approved doses for induction and/or maintenance in Crohn´s disease prior to screening for the study. For induction: 1 subcutaneous dose of 400 mg, followed by the same dose 2 and 4 weeks after. For maintenance: 400 mg subcutaneously every 2 to 4 weeks.
- Anti-integrin: at least 14 weeks treatment of the approved dose for induction and/or maintenance in Crohn´s disease prior to screening for the study. For induction: Vedolizumab 300 mg. For maintenance: Vedolizumab 300 mg every 4 to 8 weeks.
- Anti-interleukin (IL)-12/23: at least 16 weeks treatment of the approved dose in Crohn´s disease prior to screening for the study. For induction: Ustekinumab, approximately 6mg/kg intravenously initially then followed by 90 mg subcutaneously every 8 weeks.
-
Women of childbearing potential (WCBP) must have negative serum pregnancy test at screening (sensitive to 25 international units [IU] human chorionic gonadotropin [hCG]). Both WCBP or male participants participating in this study, with a WCBP as partner, must agree to use an adequate method of contraception during the entire duration of the study. An adequate method of contraception is defined as complete, non-periodic sexual abstinence (refraining from heterosexual intercourse), single-barrier method, vasectomy, adequate hormonal contraception (to have started at least 7 days prior to Screening visit), or an intra-uterine device (to have been in place for at least 2 months prior to Screening visit).
-
Concomitant rectovaginal or rectovesical fistula(s).
-
Participant naïve to prior specific medical treatment for complex perianal fistula(s) including immunosuppressant (IS) or anti-TNFs.
-
Presence of a perianal collection >2 cm in at least two dimensions on the central reading MRI at Screening visit that was not adequately drained as confirmed by the surgeon during the preparation procedure (week -3 to day 0).
-
Severe rectal and/or anal stenosis and/or severe proctitis (defined as the presence of large >0.5 cm ulcers in the rectum) that make impossible to follow the surgery procedure manual.
-
Participant with diverting stomas.
-
Active, uncontrolled infection requiring parenteral antibiotics.
-
Participant with ongoing systemic or rectal steroids for CD in the last 2 weeks prior to the Preparation visit.
-
Participants with major alteration on any of the following laboratory tests or increased risk for the surgical procedure:
- Serum creatinine levels >1.5 times the ULN
- Total bilirubin >1.5 ULN
- Aspartate Transaminase (AST)/ Alanine Transaminase (ALT) >3 times ULN
- Hemoglobin <10.0 g/dL
- Platelets <75.0*10^9/L
- Albuminemia <3.0 g/dL
-
Suspected or documented infectious enterocolitis within two weeks prior to Screening visit.
-
Any prior invasive malignancy diagnosed within the last 5 years prior to Screening visit. Participants with basal-cell carcinoma of the skin completely resected outside the perineal region can be included.
-
Current or recent (within 6 months prior to the Screening visit) history of severe, progressive, and/or uncontrolled hepatic, haematological, gastrointestinal (GI) (other than CD), renal, endocrine, pulmonary, cardiac, neurological or psychiatric disease that may result in participants increased risk from study participation and/or lack of compliance with study procedures.
-
Participants with primary sclerosing cholangitis.
-
Participants with known chronically active hepatopathy of any origin, including cirrhosis and participants with persistent positive Hepatitis B Virus (HBV) surface antigen (HBsAg) and quantitative HBV polymerase chain reaction (PCR), or positive serology for Hepatitis C Virus (HCV) and quantitative HCV PCR within 6 months prior to Screening.
-
Congenital or acquired immunodeficiencies, including participants known to be HIV carriers
-
Known allergies or hypersensitivity to penicillin or aminoglycosides; Dulbecco Modified Eagle's Medium (DMEM); bovine serum; local anaesthetics or gadolinium (MRI contrast).
-
Contraindication to MRI scan (example, due to the presence of pacemakers, hip replacements or severe claustrophobia).
-
Severe trauma within 6 months prior to Screening visit.
-
Pregnant or breastfeeding women.
-
Participants who do not wish to or cannot comply with study procedures.
-
Participants currently receiving, or having received any investigational drug within 3 months prior to Screening visit.
-
Participants previously treated with Cx601 or other allogeneic stem-cell therapy cannot be enrolled into this clinical study.
-
Any major surgery of the GI tract (including one or more segments of the colon or terminal ileum) within 6 months prior the screening or any minor surgery of the GI tract within 3 months prior to screening.
-
Participants who had local perianal surgery other than drainage for the fistula within 6 months prior to the Screening visit, or those who may need surgery in the perianal region for reasons other than fistulas at the time of inclusion in the study.
-
Contraindication to the anaesthetic procedure.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo Placebo Placebo (saline) 24 milliliters (mL) was administered once by local injection. Cx601 Cx601 Cx601 expanded adipose-derived stem cells (eASCs) 120 million cells (5 million cells per mL) was administered once by local injection.
- Primary Outcome Measures
Name Time Method Percentage of Participants With Combined Remission at Week 24 Week 24 Combined remission was defined as the closure of all treated external openings that were draining at baseline despite gentle finger compression and absence of collection(s) \>2 cm (in at least 2 dimensions) of the treated perianal fistula(s) confirmed by blinded central magnetic resonance imaging (MRI) assessment. Percentages are rounded off to whole number at the nearest decimal.
- Secondary Outcome Measures
Name Time Method Percentage of Participants With Clinical Remission at Week 24 Week 24 Clinical remission was defined as closure of all treated external openings that were draining at baseline despite gentle finger compression. Percentages are rounded off to whole number at the nearest decimal.
Time to Clinical Remission at Week 24 Week 24 Time to clinical remission was defined as the time from treatment start to first visit with closure of all treated external openings that were draining at baseline despite gentle finger compression, as clinically assessed.
Percentage of Participants With Combined Remission at Week 52 Week 52 Combined remission was defined as the closure of all treated external openings that were draining at baseline despite gentle finger compression, and absence of collections \>2 cm (in at least 2 dimensions) confirmed by blinded central MRI assessment. Percentages are rounded off to whole number at the nearest decimal.
Percentage of Participants With Clinical Remission at Week 52 Week 52 Clinical remission was defined as closure of all treated external openings that were draining at baseline despite gentle finger compression. Percentages are rounded off to whole number at the nearest decimal.
Percentage of Participants With Clinical Response at Week 24 Week 24 Clinical response was defined as closure of at least 50 percent (%) of all treated external openings that were draining at baseline despite gentle finger compression. Percentages are rounded off to whole number at the nearest decimal.
Percentage of Participants With Clinical Response at Week 52 Week 52 Clinical response was defined as closure of at least 50% of all treated external openings that were draining at baseline, despite gentle finger compression. Percentages are rounded off to whole number at the nearest decimal.
Time to Clinical Remission at Week 52 Week 52 Time to clinical remission was defined as the time from treatment start to first visit with closure of all treated external openings that were draining at baseline despite gentle finger compression, as clinically assessed.
Time to Clinical Response at Week 24 Week 24 Time to clinical response was defined as the time from treatment start to first visit with closure of at least 50% of all treated external openings that were draining at baseline, despite gentle finger compression, as clinically assessed.
Time to Clinical Response at Week 52 Week 52 Time to clinical response was defined as time from treatment start to first visit with closure of at least 50% of all treated external openings that were draining at baseline despite gentle finger compression, as clinically assessed.
Percentage of Participants With Relapse by Week 52 After Achieving Combined Remission at Week 24 From Week 24 to Week 52 Relapse was defined as reopening of any of the treated fistulas external openings with active drainage as clinically assessed, or the development of a perianal fluid collection \>2 cm of the treated perianal fistula confirmed by centrally read MRI assessment in participants who were in combined remission at week 24. Percentages are rounded off to whole number at the nearest decimal.
Number of Participants With Treatment-emergent Adverse Events (TEAEs), Treatment-emergent Serious Adverse Events (TESAEs), and Treatment-emergent Adverse Events of Special Interest (TEAESIs) From first dose of study drug to end of follow up period (up to Week 52) An adverse event(AE)=any untoward medical occurrence in a clinical investigation participant receiving a medicinal product; it did not necessarily have to have a causal relationship with this treatment. Serious adverse event(SAE)=any untoward medical occurrence that at any dose resulted in death, was life-threatening, required inpatient hospitalization/prolongation of existing hospitalization, resulted in persistent or significant disability/incapacity, or was a congenital abnormality/birth defect, or was a medically significant event or required intervention to prevent at least one of the outcomes listed above, or was a suspected transmission of an infectious agent. AESIs included tumorigenicity, ectopic tissue formation, hypersensitivity reactions, transmission of infectious agents, immunogenicity/alloimmune reactions, and medication errors, as reported by the investigator. TEAE=AE whose onset occurred, severity worsened, or intensity increased after receiving the study treatment.
Number of Participants With Clinically Significant Changes in Vital Sign Parameters From first dose of study drug to end of follow up period (up to Week 52) Vital signs included measurement of pulse rate, systolic and diastolic blood pressure, respiratory rate, and body temperature. Clinically significant vital signs assessment was based on investigator interpretation. Number of participants with clinically significant changes in vital signs were reported.
Number of Participants With Clinically Significant Changes in Laboratory Parameters From first dose of study drug to end of follow up period (up to Week 52) Laboratory parameters included blood chemistry and hematology. Clinically significant laboratory parameters assessment was based on investigator interpretation. Number of participants with clinically significant changes in laboratory parameters (hematology and blood chemistry) were reported.
Trial Locations
- Locations (159)
Emory University
🇺🇸Atlanta, Georgia, United States
The University of Chicago Medicine - Colon & Rectal Surgery
🇺🇸Chicago, Illinois, United States
GZA ziekenhuizen - Campus Sint-Vincentius - Gastro-enterology
🇧🇪Antwerpen, Belgium
Cleveland Clinic
🇺🇸Cleveland, Ohio, United States
Allegheny General Hospital
🇺🇸Pittsburgh, Pennsylvania, United States
Boston Medical Center
🇺🇸Boston, Massachusetts, United States
Baylor College of Medicine (BCM) - Gastroenterology
🇺🇸Houston, Texas, United States
University of Miami Hospital
🇺🇸Miami, Florida, United States
Icahn School of Medicine at Mount Sinai
🇺🇸New York, New York, United States
Bispebjerg Hospital
🇩🇰Kobenhavn, Copenhague, Denmark
Aarhus University Hospital - Department of Hepatology and Gastroenterology, Lever-Mave- og Tarmsygdomme Klinik, krydspunkt C216
🇩🇰Aarhus, Denmark
Rush University Medical Center
🇺🇸Chicago, Illinois, United States
Hartford Hospital - Gastroenterology
🇺🇸Farmington, Connecticut, United States
MedStar Georgetown University Hospital
🇺🇸Washington, District of Columbia, United States
University Medical Center - New Orleans
🇺🇸New Orleans, Louisiana, United States
Massachussetts General Hospital
🇺🇸Boston, Massachusetts, United States
Morristown Medical Center - Gastroenterology
🇺🇸Morristown, New Jersey, United States
University of Alberta
🇨🇦Edmonton, Alberta, Canada
University of Virginia
🇺🇸Charlottesville, Virginia, United States
Carilion Clinic
🇺🇸Roanoke, Virginia, United States
UT Southwestern Medical Center - Gastroenterology - Gastroenterology
🇺🇸Dallas, Texas, United States
Swedish Medical Center
🇺🇸Seattle, Washington, United States
AZ Delta vzw - Maag-darm-leverziekten
🇧🇪Roeselare, West-Vlaanderen, Belgium
Kensington Screening Clinic - Gastroenterology
🇨🇦Toronto, Ontario, Canada
CHU Amiens-Picardie
🇫🇷AMIENS cedex 1, Picardie, France
Centre Hospitalier de l'Universite de Montreal
🇨🇦Montreal, Quebec, Canada
Odense Universitetshospital
🇩🇰Odense, Denmark
CHRU Hopital De Pontchaillou
🇫🇷Rennes, Ille-et-Vilaine, France
Policlinico Universitario Campus Biomedico - UOC di Gastroenterologia
🇮🇹Roma, Italy
Klinikum der Johann Wolfgang Goethe-Universitat
🇩🇪Frankfurt/Main, Hessen, Germany
Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont - I. sz. Belgyogyaszati Klinika
🇭🇺Szeged, Csongrad, Hungary
Klinikum der Universitat Munchen - Campus Grosshadern
🇩🇪Munchen, Bayern, Germany
Universita degli studi di Pisa
🇮🇹Pisa, Italy
Azienda Ospedaliera Universitaria Integrata Verona (AOUI) -
🇮🇹Verona, Italy
Hospital del Mar
🇪🇸Barcelona, Spain
H.U.V. del Rocio
🇪🇸Sevilla, Spain
C.H.U. de Pontevedra
🇪🇸Pontevedra, Spain
OHSU Digestive Health Center
🇺🇸Portland, Oregon, United States
Kaiser Permamente
🇺🇸San Francisco, California, United States
University of California San Francisco
🇺🇸San Francisco, California, United States
Vanderbilt University Medical Center
🇺🇸Nashville, Tennessee, United States
University of Utah
🇺🇸Salt Lake City, Utah, United States
Hopital Saint Louis - Gastro-hepatoenterologie
🇫🇷Paris, Ile-de-France, France
Centre Hospitalier Lyon Sud
🇫🇷Pierre-Benite, Rhone, France
St. Mark's Hospital
🇬🇧Harrow, London, City Of, United Kingdom
Hospital Universitario Fundacion Jimenez Diaz
🇪🇸Madrid, Spain
Scottsdale Mayo Clinic
🇺🇸Scottsdale, Arizona, United States
University of Southern California (USC) Norris Comprehensive Cancer Center
🇺🇸Los Angeles, California, United States
UC Irvine Medical Center - Chao Family Comprehensive Cancer
🇺🇸Orange, California, United States
Inland Empire Liver Foundation
🇺🇸Rialto, California, United States
Vallejo Hospital and Medical Offices
🇺🇸Vallejo, California, United States
Cedar-Sinai Medical Center
🇺🇸West Hollywood, California, United States
Cleveland Clinic Florida
🇺🇸Weston, Florida, United States
Carle Foundation Hospital
🇺🇸Urbana, Illinois, United States
Indiana University - Colon and Rectal
🇺🇸Indianapolis, Indiana, United States
University of Kansas Sxchool of Medicine
🇺🇸Kansas City, Kansas, United States
Digestive Health Center of Louisiana
🇺🇸Baton Rouge, Louisiana, United States
Colon and Rectal Surgery Associates
🇺🇸Metairie, Louisiana, United States
Johns Hopkins Medicine - The Johns Hopkins Hospital
🇺🇸Baltimore, Maryland, United States
University of Maryland
🇺🇸Baltimore, Maryland, United States
University of Massachusetts - colon & rectal surgery
🇺🇸Worcester, Massachusetts, United States
Lahey Hospital & Medical Center
🇺🇸Burlington, Massachusetts, United States
Barnes-Jewish Hospital - Gastroenterology
🇺🇸Saint Louis, Missouri, United States
Albany Medical Center
🇺🇸Albany, New York, United States
North Shore University Hospital - Gastroenterology
🇺🇸Manhasset, New York, United States
NYU Langone Medical Center
🇺🇸New York, New York, United States
Weill Medical College of Cornell University
🇺🇸New York, New York, United States
Stony Brook University Medical Center
🇺🇸New York, New York, United States
Columbia University Medical Center
🇺🇸New York, New York, United States
Lenox Hill Hospital
🇺🇸New York, New York, United States
Harvard Medical School-Beth Israel Deaconess Medical Center
🇺🇸Hershey, Pennsylvania, United States
Penn State Hershey Medical Center - Surgery
🇺🇸Hershey, Pennsylvania, United States
University Surgical Associates-Rhode Island Hospital
🇺🇸Providence, Rhode Island, United States
Rapid City Medical Center
🇺🇸Rapid City, South Dakota, United States
Virginia Mason Medical Center - Gastroenterology
🇺🇸Seattle, Washington, United States
CHU de Liege - Domaine Universitaire du Sart Tilman
🇧🇪Liege, Belgium
Imelda Ziekenhuis
🇧🇪Antwerpen, Belgium
(G.I.R.I.) GI Research Institute
🇨🇦Vancouver, British Columbia, Canada
Ottawa Hospital
🇨🇦Ottawa, Ontario, Canada
Mount Sinai Hospital - Toronto - Gastroenterology
🇨🇦Toronto, Ontario, Canada
McGill University Health Centre - Montreal General Hospital
🇨🇦Montreal, Quebec, Canada
NH Hospital a.s.
🇨🇿Horovice, Beroun, Czechia
FN Hradec Kralove
🇨🇿Hradec Kralove, Czechia
CHU de Clermont-Ferrand - Estaing
🇫🇷Clermont-Ferrand cedex 1, Auvergne, France
Hopital Beaujon
🇫🇷Clichy, Ile-de-France, France
CHRU de Nancy -Hopital Brabois Adultes - Service d'Hepato- Gastroenterologie
🇫🇷Vandoeuvre-les-Nancy, Lorraine, France
Universitatsklinikum Erlangen
🇩🇪Erlangen, Bayern, Germany
Paris St. Joseph Hospital
🇫🇷Paris, France
Universitatsklinikum Dresden
🇩🇪Dresden, Sachsen, Germany
Rabin Med Ctr Beilinson Hosp
🇮🇱Petah Tikva, HaMerkaz, Israel
Istituto Clinico Humanitas Rozzano, IRCCS - IBD Center
🇮🇹Rozzano, Milano, Italy
Semmelweis Egyetem
🇭🇺Budapest, Pest, Hungary
Rambam Medical Centre
🇮🇱Haifa, HaZafon, Israel
Chaim sheba Medical Center
🇮🇱Tel Hashomer, Tel-Aviv, Israel
Ospedale Santissima Annunziata
🇮🇹Cento, Ferrara, Italy
Shaare Zedek Medical Center - Gastroenterology
🇮🇱Jerusalem, Yerushalayim, Israel
AOU Policlinico di Modena - Gastroenterologia
🇮🇹Modena, Italy
Hadassah Medical Organization, Hadassah Medical Center, Ein-
🇮🇱Jerusalem, Yerushalayim, Israel
II Universita degli Studi di Napoli
🇮🇹Napoli, Italy
Policlinico S. Orsola Malpighi, AOU di Bologna-U.O. di Medicina Interna.
🇮🇹Bologna, Italy
Gastroenterology Section
🇮🇹Palermo, Italy
Policlinico Universitario Agostino Gemelli
🇮🇹Roma, Italy
Azienda Ospedaliero Universitaria S.Maria della Misericordia - Gastroenterologia
🇮🇹Udine, Italy
A.O. San Camillo Forlanini
🇮🇹Roma, Italy
Complesso Integrato Columbus
🇮🇹Roma, Italy
Centrum Medyczne Melita Medical
🇵🇱Wroclaw, Dolnoslaskie, Poland
Uniwersytecki Szpital Kliniczny im. Wojskowej Akademii Medycznej Centralny Szpital Weteranow
🇵🇱Lodz, Lodzkie, Poland
Wielospecjalistyczny Szpital Medicover
🇵🇱Warszawa, Mazowieckie, Poland
Centralny Szpital Kliniczny MSWiA w Warszawie
🇵🇱Warszawa, Poland
University of Puerto Rico School of Medicine
🇵🇷San Juan, Puerto Rico
H.U. G.Trias i Pujol
🇪🇸Badalona, Barcelona, Spain
Corporacio Sanitaria Parc Tauli
🇪🇸Sabadell, Barcelona, Spain
Hospital Universitario Son Espases
🇪🇸Palma de Mallorca, Baleares, Spain
Hospital Universitario de Fuenlabrada
🇪🇸Fuenlabrada, Madrid, Spain
Hospital de Sagunto
🇪🇸Sagunto, Valencia, Spain
Hospital Universitario Puerta de Hierro Majadahonda
🇪🇸Majadahonda, Madrid, Spain
Hospital Clinic de Barcelona
🇪🇸Barcelona, Spain
Hospital Universitario Ramon y Cajal
🇪🇸Madrid, Spain
Hospital Clinico San Carlos
🇪🇸Madrid, Spain
Linkoping University Hospital - Department of Surgery
🇸🇪Linkoping, Ostergotlands Lan [se-05], Sweden
Addenbrooke's Hospital
🇬🇧Cambridge, Cambridgeshire, United Kingdom
NHS Greater Glasgow and Clyde - Glasgow Royal Infirmary (GRI)
🇬🇧Glasgow, Glasgow City, United Kingdom
Guys & St Thomas
🇬🇧London, London, City Of, United Kingdom
Nottingham University Hospitals NHS Trust - Surgery
🇬🇧Nottingham, Nottinghamshire, United Kingdom
University Colleague London Hospital (UCLH)
🇬🇧London, United Kingdom
Wythenshawe Hospital - Gastroenterology
🇬🇧Manchester, United Kingdom
Northern General Hospital
🇬🇧Sheffield, United Kingdom
UC San Diego Health Systems
🇺🇸La Jolla, California, United States
Hospital Universitario La Paz
🇪🇸Madrid, Spain
Mayo Clinic - Gastroenterology
🇺🇸Jacksonville, Florida, United States
Northwestern University
🇺🇸Chicago, Illinois, United States
Hospital Universitario 12 de Octubre
🇪🇸Madrid, Spain
University of Nevada School of Medicine
🇺🇸Las Vegas, Nevada, United States
Dartmouth Hitchcock Medical Center - Cancer Center
🇺🇸Lebanon, New Hampshire, United States
Thomas Jefferson University Hospital
🇺🇸Philadelphia, Pennsylvania, United States
AZ Groeninge - Campus Kennedylaan - Gastro-enterology
🇧🇪Kortrijk, West-Vlaanderen, Belgium
Centre Hospitalier Universitaire De Toulouse - Hopital De Ra
🇫🇷Toulouse cedex 09, Haute-Garonne, France
UZ Leuven - Campus Gasthuisberg
🇧🇪Leuven, Vlaams Brabant, Belgium
UZ Gent - Gastroenterology
🇧🇪Gent, Belgium
CHU Dinant Godinne UCL Namur
🇧🇪Namur, Belgium
CHU de Nice
🇫🇷Nice Cedex 03, Alpes-Maritimes, France
CHU Saint Etienne
🇫🇷St Priest en Jarez, Loire, France
Clinique Saint-Joseph (CHC)
🇧🇪Liege, Belgium
Debreceni Egyetem Klinikai Kozpont
🇭🇺Debrecen, Hajdu-Bihar, Hungary
Centrum Medyczne PROMED
🇵🇱Krakow, Malopolskie, Poland
Endoskopia Sp z o.o.
🇵🇱Sopot, Pomorskie, Poland
CHRU De Lille - Hopital Claude Huriez - Hepato-Gastro-Enterologie
🇫🇷Lille, Nord, France
MH Egeszsegugyi Kozpont - Gasztroenterologiai Osztaly
🇭🇺Budapest, Pest, Hungary
COPERNICUS Podmiot Leczniczy Sp. z o.o.
🇵🇱Gdansk, Poland
Florida Hospital Tampa
🇺🇸Tampa, Florida, United States
University of Louisville
🇺🇸Louisville, Kentucky, United States
Mayo Clinic College of Medicine - Division of Colon and Rectal Surgery - Division of Colon and Rectal Surgery
🇺🇸Rochester, Minnesota, United States
Yale University School of Medicine
🇺🇸New Haven, Connecticut, United States
Florida Hospital Orlando
🇺🇸Orlando, Florida, United States
USF Health South Tampa Center for Advanced Healthcare
🇺🇸Tampa, Florida, United States
University of Colorado Hospital
🇺🇸Aurora, Colorado, United States
Medical University of South Carolina
🇺🇸Charleston, South Carolina, United States
Aurora St. Luke's Medical Center
🇺🇸Milwaukee, Wisconsin, United States
Medical College of Wisconsin Hub for Collaborative Medicine - Gastroenterology and Hepatology
🇺🇸Milwaukee, Wisconsin, United States