A Pilot Open Label Trial of HIV Therapy With d4T (Stavudine), ddI (Didanosine), Nelfinavir and Hydroxyurea in Subjects With Early Asymptomatic HIV Infection
Not Applicable
Completed
- Conditions
- HIV Infections
- Registration Number
- NCT00002176
- Lead Sponsor
- Bristol-Myers Squibb
- Brief Summary
To assess the magnitude and duration of the antiviral activity in plasma and the incidence and time to total suppression of detectable HIV RNA in plasma. To assess the long-term safety and tolerability of this combination therapy and the magnitude and duration of the effect of this therapy over CD4 cell counts.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
Not provided
Exclusion Criteria
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie the antiviral activity of d4T, ddI, and nelfinavir in early HIV infection?
How does the combination of d4T, ddI, nelfinavir, and hydroxyurea compare to standard HAART regimens in early HIV treatment?
Which biomarkers correlate with sustained HIV RNA suppression in trials using nucleoside reverse transcriptase inhibitors and protease inhibitors?
What are the long-term adverse events associated with stavudine and didanosine-based HIV therapies and how are they managed?
How do alternative HIV treatment combinations involving reverse transcriptase inhibitors and protease inhibitors compare to the regimen in NCT00002176 in terms of efficacy and safety?
Trial Locations
- Locations (1)
Univ of California at San Francisco Gen Hosp
🇺🇸San Francisco, California, United States
Univ of California at San Francisco Gen Hosp🇺🇸San Francisco, California, United States