临床试验/NCT06853119

NCT06853119尚未招募不适用

Study on Brain Function and Structural Changes in Patients with Trigeminal Neuralgia Based on Magnetic Resonance Imaging.

Tongji Hospital0 个研究点目标入组 120 人开始时间: 2025年3月10日最近更新: 2025年2月28日

适应症

试验速览

阶段: 不适用
状态: 尚未招募
发起方: Tongji Hospital
入组人数: 120
主要终点: Scanning sequence of magnetic resonance imaging (MRI)

研究概览研究设计入排标准结局指标研究者记录与标识符相似试验

研究概览

简要总结

This study intends to use MRI technology to analyze the dynamic changes and microstructure changes of the brain network in patients with trigeminal neuralgia, evaluate the blood-brain barrier and water exchange rate, and further analyze their correlation with clinical indicators, so as to explore the changes in brain structural plasticity and potential neural mechanisms

研究设计

研究类型: Observational
观察模型: Case Control
时间视角: Prospective

入排标准

年龄范围: 18 Years 至 —（Adult, Older Adult）
性别: All
接受健康志愿者: 是

入选标准

•The diagnosis was TN according to the ICHD.
•Patients requiring surgical treatment due to ineffective or intolerant treatment with carbamazepine or oxasepine before operation;
•First surgical treatment;
•Right-handed dominant;
•There was no significant loss of sensation

排除标准

•Secondary TN;
•Associated with other types of chronic pain or neuropsychiatric disorders;
•History of head trauma or stroke or cerebrovascular ischemia;
•History of microvascular decompression or other treatments (gamma knife radiosurgery, etc.);
•Unable to cooperate independently;
•Contraindications, such as uncontrolled infection, coagulopathy, etc.;
•MRIcontraindications (e.g., pacemaker, claustrophobia, etc.)

结局指标

主要结局

Scanning sequence of magnetic resonance imaging (MRI)

时间窗: Preoperative routine MRI examination

such as 3D-T1, 3D-T2, BOLD-functional MRI (fMRI), diffusion weighted imaging (DWI) (Multiple b values, such as 0,1000,2000), diffusion-prepared, arterial spin labeling (DP-ASL), Meningeal lymphatic sequence (3D T2-FLAIR ).

次要结局

Brief Pain Inventory (BPI)(Baseline, until to discharge (an average of 3 days), 3 months after surgery)
Simplified McGill pain questionnaire (SF-MPQ)(Baseline, 3 months after surgery)
Douleur Neuropathique 4 Questions (DN4)(Baseline, 3 months after surgery)
Beck Depression Inventory (BDI)(Baseline, 3 months after surgery)
Beck Anxiety Inventory (BPI)(Baseline, 3 months after surgery)
Pittsburgh Sleep Quality Index (PSQI)(Baseline, 3 months after surgery)
Blood immune inflammation indicators(Baseline)
PBC asscoated adverse reactions(24 hours after surgery, 3 months after surgery)

研究者

发起方

Tongji Hospital

申办方类型

Other

责任方

Principal Investigator

主要研究者

Feng Gao

Professor

Tongji Hospital

相似试验

进行中（未招募）

不适用

Brain Functional MRI in Older Women With Breast Cancer (Brain fMRI-BC)Breast Cancer

NCT01992432City of Hope Medical Center49

已完成

不适用

Study of Brain Changes Shaped by ExperienceHealthyNeurologic Manifestations

NCT00006424National Institute of Neurological Disorders and Stroke (NINDS)153

终止

不适用

Brain Anatomy in DystoniaDystoniaHealthy

NCT00031369National Institute of Neurological Disorders and Stroke (NINDS)189

已完成

不适用

Diffusion MRI of the AbdomenAbdominal Imaging

NCT05261633University of Wisconsin, Madison17

Unknown

不适用

Study to Investigate the Sensitivity and Specificity of 3.0 Tesla MRI for Carotid Artery PlaqueAtherosclerosis

NCT01632254Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)30