Insecticide Resistance Management in Burkina Faso and Côte D'Ivoire
- Conditions
- Malaria
- Interventions
- Registration Number
- NCT03074435
- Lead Sponsor
- Institut de Recherche pour le Developpement
- Brief Summary
This study evaluates the benefit to use 1) insecticide residual sprayings, 2) larvicides, 3) Ivermectin for domestic animals and 4) behaviour change communication strategy to complement the universal coverage with LLINs through a cluster randomized trial.
- Detailed Description
Insecticidal paint comprised of two organophosphates (OPs) and an Insect Growth Regulator (IGR). This tool targets adult mosquitoes that are resistant pyrethroids to reduce vector density.
Larvicide is a new formulation of Bacillus thuringiensis israelensis that will be implemented in major permanent breeding sites with the objective to reduce vector density.
Ivermectin will be injected to domestic animals in addition to the national campaign implemented in the study area which treats the whole population. Ivermectin reduces the survival of mosquito that blood feed on treated humans and animals.
Information, Education and Communication strategy aims to increase the adherence of the population to control tools available. Strengthening the IEC aims to increase the good use of long lasting nets.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 15776
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description LLIN + indoor residual sprayings Indoor residual sprayings LLIN+IRS arm consisted in applying, in addition to LLINs, IRS with Actellic® 300CS (Syngenta AG, Basel, Switzerland) at a target dosage of 1 g. of active ingredient (pirimiphos-methyl) per m² in every houses of the selected villages. This arm is common to both countries (Burkina Faso and Côte d'Ivoire) LLIN + Larvicide Larvicide The intervention consists in treating Anopheles breeding sites with BTI biological larvicide, in addition to LLINs. This arm was implemented in Côte d'Ivoire only. LLIN + Behaviour Change Communication BCC BCC complementary intervention (LLIN+BCC arm) was designed to target the following behaviors in the human population: (i) everyone sleep under an LLIN every night, (ii) every household and community member cleans up its environment to limits mosquito proliferation, (iii) every pregnant woman asks for, and takes the intermittent preventive treatment of malaria during pregnancy (ITP) and, (iv) people in charge of \<5 y/o children come to see an health worker within 24h in case of fever. The intervention involve one health worker from the community per 35 households. Every health worker has the objective to perform 15 home visits (15-20 min), 20 interpersonal talks (15-20 min) and 4 group talks (15-30 min) per months. LLIN+ One-health Ivermectin Ivermectin This arm consists in monthly injections of ivermectin to peri-domestic farm animals (mammals) during 4 consecutive months, oin addition to LLINs. This arm was implemented in Burkina Faso only.
- Primary Outcome Measures
Name Time Method Malaria incidence density continuous monitoring during 2 years Malaria cases (whole population, every ages) registered in the local health system.
- Secondary Outcome Measures
Name Time Method Entomological Inoculation Rate Every 8 weeks during 2 years Number of infectious bites/personn
Malaria prevalence Every 4 months during 2 years % of positive blood smears among the 0-18 y/o population as recorded during cross sectional surveys.
Trial Locations
- Locations (2)
Institut de Recherche en Sciences de la Santé
🇧🇫Bobo-Dioulasso, Burkina Faso
Institut Pierre Richet
🇨🇮Bouaké, Côte D'Ivoire