Comparative study between Amisulpride and Granisetron for prevention of postoperative nausea and vomiting in patient undergoing general Anaesthesia: A Rndomized Controlled double blind Study.
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- To evaluate the incidence of PONV in patients undergoing General anesthesia.
研究概览
简要总结
Nausea and vomiting are two of the most unpleasant and distressing event in the postoperative period with an estimated incidence of 30% in general surgical patients and as high as 80% in high risk groups.
Incidence of post operative nausea and vomiting (PONV) in high risk surgeries is very high.High risk surgeries include cholecystectomy and gyneocological and laparoscopic surgeries.Long duration surgeries are associated with increase incidence of PONV.increasing operative duration by 30 minutes may increase the risk of PONV . Increasing operative duration by 30 minutes may increase the risk of PONV by 60%. Repeated PONV can lead to more serious and undesirable consequences such as dehydration, electrolyte imbalance, increased post operative pain and aspiration of gastric content.
In this study we will be comparing amisulpride dopamine D2 receptor antagonist with granisetron 5-HT3 receptor antagonist for prevention of PONV in high surgery after general anaesthesia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 盲法
- None
入排标准
- 年龄范围
- 18.00 Year(s) 至 70.00 Year(s)（—）
- 性别
- All
入选标准
- •1.Patients willing to participate.
- •2.Patients 18-70 years of age of either gender.
- •3.ASA grade 1-3 patients.
- •4.Operative procedure requiring General Anaesthesia.
排除标准
- •Any contraindications to General Anaesthesia.
- •1.Patients with history of motion sickness.
- •2.Patients with pregnancy.
- •3.Lactating Mother.
结局指标
主要结局
To evaluate the incidence of PONV in patients undergoing General anesthesia.
时间窗: Time interval 0-6 hr,6-12 hr,12-24hr
次要结局
- To assess the secondary efficacy variables i.e.
研究者
Jay prakash ravi
IGIMS patna