Dispersion of Local Anesthetic on the Erector Spinae Plane Block in Cadavers
- Conditions
- Nerve Block
- Interventions
- Procedure: Erector Spinae Plane Block
- Registration Number
- NCT03545854
- Lead Sponsor
- Federal University of São Paulo
- Brief Summary
This study aims to better understand the dispersion of local anesthetic on the Erector Spinae Block, a new technique developed for analgesia. It consists on injection of local anesthetic around the posterior muscles of the Spine. In this study, the investigators will make the injection with coloring solution on cadavers and by dissection will note the dispersion of the solution according to injectate volume. The investigators hypothesize more volume allows bigger spread and will allow new indications of this technique in perioperative analgesia and treatment of chronic Pain
- Detailed Description
The study's methodology will include performing ultrasound guided erector spinae block in cadavers included in the study according to eligibility criteria. After signing of written consent form, the participants will be randomized on the height of the block (vertebral level - T3, T12 and L4) and the volume to be injected (10, 20 and 30ml). The block will be performed by experienced physicians on the technique by ultrasound guidance and fixed pressure measured with an in-line pressure monitor (15 psi) with the cadaver in the lateral position. The cadavers will be submitted to autopsy by standard thoracoabdominal midline incision, with the viscera removed for analysis. The cadavers will have their paraspinal muscles removed (quadratus lumborum and psoas major), the medial parietal pleura opened and the number of levels with colored solution registered, noting the spread to ventral rami of spinal nerves and to the paravertebral space.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 20
- Fresh Cadavers (not subject to formaldehyde fixation process or frozen > 24h)
- Age > 18 years
- Written informed consent signed by responsible party
- Height > 150cm and < 190cm
- Previous spinal surgery
- Severe spinal deformity
- BMI > 35 kg/m2
- Absence of a responsible party to sign the written informed consent
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description T3 30ml Erector Spinae Plane Block The cadaver will receive an ultrasound-guided Erector Spinae Plane Block with 30ml of coloring solution at the T3 vertebral level T3 10ml Erector Spinae Plane Block The cadaver will receive an ultrasound-guided Erector Spinae Plane Block with 10ml of coloring solution at the T3 vertebral level T12 20ml Erector Spinae Plane Block The cadaver will receive an ultrasound-guided Erector Spinae Plane Block with 20ml of coloring solution at the T12 vertebral level T12 10ml Erector Spinae Plane Block The cadaver will receive an ultrasound-guided Erector Spinae Plane Block with 10ml of coloring solution at the T12 vertebral level L4 20ml Erector Spinae Plane Block The cadaver will receive an ultrasound-guided Erector Spinae Plane Block with 20ml of coloring solution at the L4 vertebral level T3 20ml Erector Spinae Plane Block The cadaver will receive an ultrasound-guided Erector Spinae Plane Block with 20ml of coloring solution at the T3 vertebral level L4 30ml Erector Spinae Plane Block The cadaver will receive an ultrasound-guided Erector Spinae Plane Block with 30ml of coloring solution at the L4 vertebral level T12 30ml Erector Spinae Plane Block The cadaver will receive an ultrasound-guided Erector Spinae Plane Block with 30ml of coloring solution at the T12 vertebral level L4 10ml Erector Spinae Plane Block The cadaver will receive an ultrasound-guided Erector Spinae Plane Block with 10ml of coloring solution at the L4 vertebral level
- Primary Outcome Measures
Name Time Method Spread of Coloring Solution secondary to volume injected and vertebral level of injection 3 hours Observation of coloring solution around the spinal nerves as they exit the vertebral foramen. Comparison of number of spinal nerves colored according to the volume injected and injection site.
- Secondary Outcome Measures
Name Time Method Spread of coloring solution to paravertebral space 3 hours Observation of coloring solution on the paravertebral space. Comparison of number of levels of the paravertebral space colored according to volume injected and injection site.
Trial Locations
- Locations (1)
Irmandade da Santa Casa de Misericórdia de São Paulo
🇧🇷São Paulo, SP, Brazil