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临床试验/NCT04113356
NCT04113356招募中不适用

Clinical Relevance of Magnetic Resonance Imaging in Acute ST-Elevation Myocardial Infarction

Medical University Innsbruck2 个研究点 分布在 1 个国家目标入组 1,500 人开始时间: 2011年1月最近更新:
适应症

试验速览

阶段
不适用
状态
招募中
发起方
入组人数
1,500
试验地点
2
主要终点
Occurence of major adverse cardiovascular events

研究概览

简要总结

Cardiovascular magnetic resonance imaging enables comprehensive assessment of cardiovascular function, morphology and pathology. The investigators aim to evaluate the nature and clinical significance of magnetic resonance imaging parameters in patients presenting with first acute ST-elevation myocardial infarction.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • 未提供

排除标准

  • 未提供

结局指标

主要结局

Occurence of major adverse cardiovascular events

时间窗: 1 - 5 years

次要结局

  • Aortic pulse wave velocity and distensibility by phase contrast imaging(baseline, 4 months and 12 months)
  • Cardiac function by cine imaging(baseline, 4 months and 12 months)
  • Parameters of cardiac function by transthoracic echocardiography(baseline, 4 months and 12 months)
  • Cardiac autonomic function(baseline, 4 months and 12 months)
  • Infarct size assessment (% of left ventricular myocardial mass)(baseline, 4 months and 12 months)
  • Assessment of infarct transmurality grade (%) with late gadolinium enhancement imaging(baseline, 4 months and 12 months)
  • Occurence and area of microvascular obstruction(baseline)
  • Intramyocardial haemorrhage assessed by T2* imaging(baseline, 4 months and 12 months)
  • Tissue characterisation by T1, T2 and T2* Mapping(baseline, 4 months and 12 months)
  • Myocardial deformation by strain analysis(baseline, 4 months and 12 months)
  • Aortic pulse wave distensibility by phase contrast imaging(baseline, 4 months and 12 months)
  • Quality of life and invalidity assessment (Global Physical Activity Questionnaire)(1 - 5 years)
  • Biomarker release during the acute and subacute phase(baseline, 4 months and 12 months)
  • Plaque volume by 3D ultrasound(baseline, 12 months)
  • Chamber volumes by cine imaging(baseline, 4 months and 12 months)
  • Stroke volumes by phase contrast imaging(baseline, 4 months and 12 months)

研究者

发起方
Medical University Innsbruck
申办方类型
Other
责任方
Sponsor

研究点 (2)

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