NCT00217048已完成1 期
Effect of Oral Yohimbine on Colonic Transit: Randomized, Placebo-Controlled Trial
适应症
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- Mayo Clinic
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Colonic transit
研究概览
简要总结
This study is being done to learn if yohimbine, a naturally occurring drug, affects the speed at which food travels through the stomach, intestines and colon, and if yohimbine affects the amount of liquid you can drink in a short period of time. Understanding how yohimbine works on the gut may help develop new treatments for patients with constipation. Yohimbine has been approved by the Food and Drug Administration (FDA) for routine clinical use, however, its use as proposed in this study is considered investigational.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Healthy male or non-pregnant, non-breastfeeding female volunteers, -18-65 years old;
- •Able to provide written informed consent before participating in the study;
- •Able to communicate adequately with the investigator and to comply with the requirements for the entire study.
排除标准
- 未提供
结局指标
主要结局
Colonic transit
次要结局
- Small bowel transit time
- Gastric emptying time
- Maximum tolerated volume ingested during satiation testing
- Average stools per day
- Stool consistency
研究者
研究点 (2)
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