ELECTROENCEPHALOGRAPHIC REACTIVITY IN SEVERE ACUTE TRAUMATIC BRAIN INJURY PATIENTS TO PREDICT OUTCOME
Not Applicable
- Conditions
- Health Condition 1: S069- Unspecified intracranial injury
- Registration Number
- CTRI/2021/09/036358
- Lead Sponsor
- ational institute of Mental health and Neurosciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Patients 18 years and above with acute traumatic brain injury with Glasgow coma scale motor response <=4 anytime between day3-5 of injury
Exclusion Criteria
1.Patients with extracranial injuries
2.Haemodynamically unstable patients
3.Patient in ictal or post ictal state
4.Severe sodium disturbances (serum sodium < 130 meq/L or > 160 meq/L)
5.Severe glucose disturbances (blood glucose < 70 mg/dl or > 300 mg/dl
6.Patients in severe sepsis
7.Patient refusal
8.Patients who become conscious (e.g, BIS >80 or 95%SEF >25) at the time of application of painful stimulus
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To evaluate the incidence of EEG-R and BIS-R to painful and auditory stimuli in unconscious patients with acute severe traumatic brain injury and its correlation with the outcome assessed by GOSETimepoint: Discharge, 3rd and 6th month after injury
- Secondary Outcome Measures
Name Time Method 2.To evaluate association between EEG & BIS parameters with patientâ??s demographic and clinical detailsTimepoint: Discharge, 3rd and 6th month after injury;To study combination of various EEG parameters (such as burst suppression ratio, average amplitude, spectral edge frequency, peak power frequency, band ratios) and BIS in prediction of patientâ??s outcomeTimepoint: Discharge, 3rd and 6th month after injury;To study interrater agreement of EEG and BIS parametersTimepoint: Discharge, 3rd and 6th month after injury