Effects of calcitriol on the complications of hematopoietic stem cell transplantatio

Phase 2

• Conditions: Condition 1: Hodgkin lymphoma. Condition 2: Non-Hodgkin lymphoma. Condition 3: Multiple myeloma.; Hodgkin lymphoma; Follicular lymphoma, Non-follicular lymphoma, Mature T/NK-cell lymphomas, Other and unspecified types of non-Hodgkin lymphoma; Multiple myeloma and malignant plasma cell neoplasms; C82, C83,

• Registration Number: IRCT2016052727435N2
• Lead Sponsor: Research Center of the Hematology and Oncology and Stem Cell Transplantation, Shariati Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

age between 18 and 65 years; cases of Hodgkin’s lymphoma, non-Hodgkin’s lymphoma, or multiple myelomas; candidates for autologous peripheral blood hematopoietic stem cell transplantation. Exclusion criteria: baseline serum calcium >10.5mg/dL; baseline serum phosphorous >4.5mg/dL; history of renal stones in the past 5 years; baseline serum creatinine >1.3mg/dL; alkaline phosphatase x4 the upper limit of normal or higher; alanine transaminase >60U/L; total bilirubin >2mg/dL; sensitivity to calcitriol; disability for oral intake.

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Incidence rate of oral mucositis. Timepoint: Every day after receiveing conditionig regimen upto day 21 after transplantation. Method of measurement: visiting the oral cavitiy by clinical pharmacist.;Severity of oral mucositis. Timepoint: Every day after receiveing conditionig regimen upto day 21 after transplantation or up to day of healing of oral mucositis. Method of measurement: scoring upon WHO grading system for severity of oral mucositis.;Duration of oral mucositis condition. Timepoint: Every day after receiveing conditionig regimen upto day 21 after transplantation or up to day of healing of oral mucositis. Method of measurement: Daily visiting of the oral cavitiy by clinical pharmacist.