Optimation of mechanical ventilation in ARDS with PEEP-titration and driving pressure - a controled clinical pilo trial
Not Applicable
- Conditions
- J80Adult respiratory distress syndrome
- Registration Number
- DRKS00012286
- Lead Sponsor
- Klinik und Poliklinik für Anästhesiologie und Intensivtherapie, Universitätsklinikum Leipzig, AöR
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
1. ARDS with followed criteria (all):
a. sudden onset
b. bilaterale infiltrates in the lung
c. PaO2/FIO2 < 300
d. no evidence for a cardial reason of the lung failure
2. intubation and mechanical ventilation
Exclusion Criteria
1. age < 18 years
2. Intubation and mechanical ventilation >7 days of inclusion
3. pregnancy and the breastfeeding
4. severe cardial diseases (New York Heart
Association Klassifikation III or IV, acute Ischemia, ventricular rhythm disorders)
5. every neuromuscular disorders
6. patient in an interventional study 3 months before
7. pacemaker or other electrical implantated devices
8. high risk for death within the first 48h
9. DNR order
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Evaluation of the possibility for a decremental PEEP (positive end-expiratory pressure) titration to detect the lowest PEEP that minimizes ?P
- Secondary Outcome Measures
Name Time Method Describing the distribution of ventilation in the early stadium of ARDS (Acute respiratory distress syndrome) <br>Effects of an individualized PEEP setting with driving pressure for the distribution of ventilation<br>Determination of endexpiratory lung volume to show the effects after PEEP-titration