Impedance Threshold Device Tilt Study
Not Applicable
Terminated
- Conditions
- Orthostatic Hypotension
- Registration Number
- NCT00137319
- Lead Sponsor
- United States Army Institute of Surgical Research
- Brief Summary
This study will see if a special piece of equipment can help burn patients who have been in bed for a long time to get out of bed without feeling dizzy or faint.
- Detailed Description
To measure stroke volume, cardiac output, arterial blood pressure and cerebral blood flow velocity in human patients while they undergo exposure to head-up tilt that is designed to test their tolerance to an orthostatic challenge.
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 2
Inclusion Criteria
- Military or civilian males or females between the ages of 18-65 years
- Burn injury with at least one unburned finger for Portapres measurement
- Minimum of 96 hours bedrest or physician directive to tilt
Exclusion Criteria
- Age < 18 and > 65 years
- Facial burns when application of ITD device would cause further trauma
- Medical monitoring devices that preclude the use of the ITD
- Signs of cardiac abnormalities, autonomic dysfunction
- Chronic obstructive pulmonary disease (COPD), or any other respiratory limitations (ventilator dependent, intubated, tracheostomy) limiting use of ITD
- History of pre-syncopal/syncopal episodes or orthostatic hypotension
- History of atherosclerotic coronary heart disease
- Patients taking any kind of cardiovascular pressor medications
- Inability to obtain a Portapres pulse wave validated by blood pressure cuff with +/- 5mmHg diastolic blood pressure
- Unable to provide informed consent for self
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Inspiratory impedance during passive upright tilt will prevent orthostatic hypotension. 1 hour
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie ITD's effect on cerebral blood flow in burn patients with orthostatic hypotension?
How does ITD compare to standard-of-care interventions for managing orthostatic hypotension in burn patients?
Are there specific biomarkers that correlate with improved hemodynamic tolerance to orthostatic challenge using ITD?
What adverse events are associated with ITD use during orthostatic stress in critically ill patients?
What alternative devices or therapies are being explored for improving stroke volume and cerebral perfusion in orthostatic intolerance?
Trial Locations
- Locations (1)
US Army Institute of Surgical Research
🇺🇸Fort Sam Houston, Texas, United States
US Army Institute of Surgical Research🇺🇸Fort Sam Houston, Texas, United States