Macular Function During Anti-VEGF Treatment

• Conditions: Age Related Macular Degeneration

• Registration Number: NCT01023971
• Lead Sponsor: Royal Liverpool University Hospital

Brief Summary

The purpose of this study is to determine the changes in macular function during anti-VEGF treatment for neovascular age-related macular degeneration.

Detailed Description

Macular function will be investigated using visual acuity, contrast sensitivity, mfERG and microperimetry.

Study Timeline

• Study Start: 2009-01
• Status Verified: 2009-12
• Study First Submitted: 2009-12-01
• Study First Submitted QC: 2009-12-01
• Last Update Submitted: 2009-12-01
• Study First Posted: 2009-12-02
• Last Update Posted: 2009-12-02

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Neovascular AMD in first or second eyes
• angiographic signs of active subfoveal or juxtafoveal choroidal neovascularization (CNV)
• BCVA ≥35 ETDRS letters

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Exclusion Criteria

• Spherical equivalent ≥ ± 6 D
• Previous treatments for CNV in the studied eye

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
mfERG central ring amplitude density	12 months

Secondary Outcome Measures

Name	Time	Method
Mean retinal sensitivity (dB) in three concentric rings (4°, 8° & 12°)	12 months
Choroidal blood flow (ChBFlow) at fovea and at optic nerve head	12 months

Trial Locations

Locations (1)

Clinical Eye Research Centre; 🇬🇧 Liverpool, United Kingdom