Expanded Access of Adagrasib (MRTX849) in Patients With Advanced Solid Tumors Who Have a KRAS G12C Mutation
- Conditions
- Advanced CancerMetastatic CancerMalignant Neoplasm
- Registration Number
- NCT05162443
- Lead Sponsor
- Bristol-Myers Squibb
- Brief Summary
The objective of this EAP is to provide expanded access of adagrasib (MRTX849) to patients with previously treated advanced solid tumors harboring a KRAS G12C mutation.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- APPROVED_FOR_MARKETING
- Sex
- All
- Target Recruitment
- Not specified
- Histologically or cytologically confirmed diagnosis of an advanced/metastatic solid tumor
- Confirmed presence of a KRASG12C mutation
- Ineligible for an ongoing clinical trial of MRTX849
- No available or not eligible for standard of care treatment
- Adequate organ function
- CNS Metastases (within set parameters) are allowed
- ECOG performance status of ≤ 2
- History of intestinal disease, inflammatory bowel disease, major gastric surgery, or other gastrointestinal conditions likely to alter absorption of MRTX849 treatment or result in inability to swallow
- Prior therapy targeting a KRAS G12C mutation
- Other active cancer
Study & Design
- Study Type
- EXPANDED_ACCESS
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (11)
California Pacific Medical Center
🇺🇸San Francisco, California, United States
Providence Medical Group Santa Rosa - Cancer Center
🇺🇸Santa Rosa, California, United States
Hartford Hospital
🇺🇸Hartford, Connecticut, United States
Piedmont Cancer Institute
🇺🇸Atlanta, Georgia, United States
Mayo Clinic - Rochester
🇺🇸Rochester, Minnesota, United States
Renown Health
🇺🇸Reno, Nevada, United States
Lehigh Valley Cancer Institute
🇺🇸Allentown, Pennsylvania, United States
Lumi Research
🇺🇸Kingwood, Texas, United States
Virginia Cancer Institute
🇺🇸Richmond, Virginia, United States
Seattle Integrative Cancer Center
🇺🇸Renton, Washington, United States
Scroll for more (1 remaining)California Pacific Medical Center🇺🇸San Francisco, California, United States