The effects of cannabidiol (CBD) on psychosocial stress, situational anxiety and nausea experienced in a virtual reality environment

Phase 2

Recruiting

• Conditions: Psychosocial stress; Situational anxiety; Motion sickness; Cybersickness; Mental Health - Anxiety; Mental Health - Other mental health disorders

• Registration Number: ACTRN12623000872639
• Lead Sponsor: niversity of Sydney

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-08-15
• Last Update Posted: 18 March 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 74

Inclusion Criteria

a) Healthy adults aged between 18-50 years.
b) Proficient in English (able to provide informed consent).
c) Residing in Greater Sydney NSW Australia.
d) Willing to follow the protocol requirements.

Exclusion Criteria

a)Self-reported regular use (i.e., more than twice weekly) of any cannabis or cannabinoid-containing products including CBD in the past two weeks.
b)Self-reported regular use (i.e., more than twice weekly) use of psychotropic drugs (licit or illicit) (e.g., cannabis, amphetamines, cocaine, ecstasy (MDMA), LSD (acid), antidepressants, opioids, benzodiazepines) within the past two weeks.
c)Self-reported regular use (i.e., more than twice weekly) of medication that may affect the stress response (e.g., corticosteroids, beta-blockers) within the past two weeks
d)Self-reported history of allergic reactions (e.g., urticaria or anaphylaxis) to cannabis or cannabis-based products.
e)Self-reported history of liver disease, renal disease, epilepsy or heart disease (currently (i.e., within the past 2-weeks) controlled high blood pressure <140/90mmHg is acceptable)
f)Current (i.e., within the past 2-weeks) otologic (vestibular) disease
g)A history of repeated episodes of syncope
h)Pregnant, lactating, or trying to conceive.
i)Self-reported drug and/or alcohol dependence (or suspected drug and/or alcohol dependence as determined by the trial physician)
j)A medically diagnosed anxiety disorder (e.g., social anxiety disorder) within the past 12 months
k)Current suicide ideation (i.e., a score >0 on Question 9 of the Patient Health Questionnaire) or suspected suicide ideation as determined by the trial physician.
l)Current depression, anxiety, and stress scores outside the healthy range of the Depression Anxiety Stress Scale-21 (> moderate on DASS-21 for depression, anxiety and stress).
m)An uncontrolled chronic medical condition (mental or physical)
n)Self-reported high vulnerability to cybersickness or motion sickness.
o)Frequent (> weekly) use of VR technologies, which tends to produce desensitisation towards motion sickness.
p)Self-reported intense fear of heights.

Study & Design

• Study Type: Interventional
• Study Design: Not specified