Study of Buprenorphine augmentation in regular treatment of resistant obsessive compulsive disorder
- Conditions
- Obsessive compulsive disorder.Obsessive compulsive disorder
- Registration Number
- IRCT2015062422901N1
- Lead Sponsor
- Vice chancellor of research of Hamadan university of medical scienses
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 23
(a) patients with primary Obsessive Compulsive Disorder who received minimum of 2 different Selective Serotonin Reuptake Inhibitor for a period of 16 weeks in two separate rotations but failed to respond to treatment (less than 25% in symptom regression); (b)age between 18 to 60 years old; (c) scores of more than 16 according to Yale-Brown Obsessive Compulsive Scale (Y-COBS)
Exclusion criteria: (a) receiving any other opioid medications; (b) having any history of alcohol or substance abuse; (c) received any electroconvulsive therapy during the last two months; (d) having any serious diseases which require long term medical treatment such as diabetes, high blood pressure, rheumatoid arthritis, cardiovascular diseases, respiratory diseases, thyroid diseases or gastrointestinal diseases; (e) any signs of psychotic disorders, such as bi-polar schizophrenia or similar; (f)being at a great risk of suicide attempt; (g) any pregnant woman or any woman who intend pregnancy during the next 3 months; (h) any serious- non psychological diseases; (i)any upcoming surgery which needs anesthesia or deep Sedation; (j) patient is a candidate to receive electroconvulsive therapy.
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Obsessive Compulsive Disorder severity. Timepoint: before intervention and end of 1,2,3,4,5 weeks after that. Method of measurement: Yale Brown Scale.
- Secondary Outcome Measures
Name Time Method