NL-OMON48065CompletedNot Applicable
The Role of microbial produced ethanol in etiology of Non-Alcoholic Steatohepatitis (ETHANASH trial) - ETHANASH trial
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Academisch Medisch Centrum
- Enrollment
- 20
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Observational
Eligibility Criteria
- Ages
- 18 to 64 (—)
Inclusion Criteria
- •- Diagnosis of NASH on liver biopsy taken on clinical grounds at the outpatient
- •- 18-65 years of age
- •- BMI > 25 kg/m2
- •- Subjects should be able to give informed consent,
- •Healthy controls:
- •- BMI >25 kg/m2
- •- 18-65 years of age
- •- Subjects should be able to give informed consent
Exclusion Criteria
- •- Primary lipid disorder
- •- Known genetic basis for insulin resistance or glucose intolerance
- •- Ethanol intake
- •- Pregnancy, females who are breastfeeding
- •- Hepatitis B and/or C
- •- Auto-immune hepatitis
- •- Wilson disease/ alpha 1-antitripsine deficiency
- •- Hemochromatosis
- •- Use of drugs interacting with Fomepizole (products requiring CYP2E1 for
- •metabolizing).
- •- Use of drugs interacting with Clindamycine, metronidazole or ciprofloxacin.
Investigators
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