NCT03735797进行中（未招募）不适用
Cancer Stem Cells in Acute Leukemia
适应症
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- ARID5B polymorphism/mutation status
研究概览
简要总结
Descriptive study of acute leukemia patients. Bone marrow aspirate or peripheral blood samples will be analyzed by next-generation sequencing for novel gene signatures and variations in transcriptional and epigenetic regulatory elements such as ARID5B and SALL4 variants.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 1 Month 至 30 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Newly diagnosed or relapsed acute leukemia (AML or ALL)
- •Plan to undergo diagnostic bone marrow aspirate or peripheral blood if clinically indicated (i.e. WBC>50,000 and bone marrow contraindicated)
- •Age 1 month to 30 years
- •Understand and provide informed consent (subject if>18, legal guardian if<18)
排除标准
- •Age 0 to 4 weeks
- •Treatment related leukemia or leukemia secondary to MDS
- •Situations that would limit compliance with study requirements or ability to willingly give consent
结局指标
主要结局
ARID5B polymorphism/mutation status
时间窗: 5 years
Correlation of our experimentally validated Arid5b dependent transcriptional signature with primary patient samples measured by patient ARID5B expression and polymorphisms.
次要结局
未报告次要终点
研究者
研究点 (1)
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