Telerehabilitation Program and Detraining in Patients With Post-COVID-19 Sequelae

Not Applicable

Completed

• Conditions: COVID-19 Acute Respiratory Distress Syndrome
• Interventions: Other: Telerehabilitation program

• Registration Number: NCT05866224
• Lead Sponsor: Campus docent Sant Joan de Déu-Universitat de Barcelona

Brief Summary

The primary objective of this study is to evaluate the effects of a 15-week home telerehabilitation program and a detraining period on cardiorespiratory fitness and muscular efficiency in patients with post-COVID-19 sequelae compared to a control group of COVID-19 patients. We hypothesize that cardiorespiratory fitness and muscular efficiency significantly improve in patients who carry out the home telerehabilitation program. However, the cardiorespiratory and muscular adaptations achieved and tolerance to exercise are lost over time as an effect of detraining.

Detailed Description

Not available

Study Timeline

• Study Start: 2021-01-01
• Primary Completion: 2023-01-01
• Status Verified: 2023-05
• Study Completion: 2023-05-01
• Study First Submitted: 2023-05-16
• Study First Submitted QC: 2023-05-16
• Last Update Submitted: 2023-05-16
• Study First Posted: 2023-05-19
• Last Update Posted: 2023-05-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 130

Inclusion Criteria

• age > 18 years
• molecular diagnosis (reverse transcription polymerase chain reaction [RT-PCR]) of infection by SARS-CoV-2
• post-COVID-19 symptomatology

Exclusion Criteria

• severe neurological disease
• active oncological disease
• neuromuscular disease and/or orthopedic disorders impeding normal development of cardiopulmonary exercise test
• the absence of signed informed consent

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Supervised home telerehabilitation program	Telerehabilitation program	COVID-19 patients will perform a total of 15 weeks of a telerehabilitation program combined with aerobic and strength exercises using the circuit training methodology. COVID-19 patients will carry out 3 weekly sessions on non-consecutive days to avoid unnecessary overload and maximize the adaptations, completing a total of 45 sessions

Primary Outcome Measures

Name	Time	Method
Ventilatory efficiency	1 week per group	VE/VCO2 slope
Mechanical efficiency	1 week per group	Delta efficiency in percentage
Cardiorespiratory fitness: relative oxygen uptake	1 week per group	relative peak oxygen uptake in L/min
Exercise capacity during cardiopulmonary exercise test	1 week per group	Exercise time in minutes and seconds
Cardiorespiratory fitness: absolute oxygen uptake	1 week per group	absolute peak oxygen uptake in L/min
Power output during pedaling	1 week per group	Power output in watts

Secondary Outcome Measures

Name	Time	Method
Respiratory exchange ratio	1 week per group	RER
ventilatory equivalent for carbon dioxide	1 week per group	VE/VCO2
Minute ventilation	1 week per group	Ventilation in L/min
End-tidal partial pressure of oxygen	1 week per group	PetO2 in mmHg
ventilatory equivalent for oxygen	1 week per group	VE/VO2
end-tidal partial pressure of carbon dioxide	1 week per group	PetCO2 in mmHg
Weight of COVID-19 patients	1 week per group	Weight in kg
Height of COVID-19 patients	1 week per group	Height in meters
Body mass index of COVID-19 patients	1 week per group	BMI in kg/m2

Trial Locations

Locations (1)

Manuel Vicente Garnacho Castaño; 🇪🇸 Sant Boi De Llobregat, Barcelona, Spain