Effects of a Telerehabilitation Program and Detraining on Cardiorespiratory Fitness in Patients With Post-COVID-19 Sequelae
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- COVID-19 Acute Respiratory Distress Syndrome
- Sponsor
- Campus docent Sant Joan de Déu-Universitat de Barcelona
- Enrollment
- 130
- Locations
- 1
- Primary Endpoint
- Mechanical efficiency
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
The primary objective of this study is to evaluate the effects of a 15-week home telerehabilitation program and a detraining period on cardiorespiratory fitness and muscular efficiency in patients with post-COVID-19 sequelae compared to a control group of COVID-19 patients. We hypothesize that cardiorespiratory fitness and muscular efficiency significantly improve in patients who carry out the home telerehabilitation program. However, the cardiorespiratory and muscular adaptations achieved and tolerance to exercise are lost over time as an effect of detraining.
Investigators
Manuel Vicente Garnacho Castano
Coordinator of the DAFNiS research group
Campus docent Sant Joan de Déu-Universitat de Barcelona
Eligibility Criteria
Inclusion Criteria
- •age \> 18 years
- •molecular diagnosis (reverse transcription polymerase chain reaction \[RT-PCR\]) of infection by SARS-CoV-2
- •post-COVID-19 symptomatology
Exclusion Criteria
- •severe neurological disease
- •active oncological disease
- •neuromuscular disease and/or orthopedic disorders impeding normal development of cardiopulmonary exercise test
- •the absence of signed informed consent
Outcomes
Primary Outcomes
Mechanical efficiency
Time Frame: 1 week per group
Delta efficiency in percentage
Cardiorespiratory fitness: relative oxygen uptake
Time Frame: 1 week per group
relative peak oxygen uptake in L/min
Ventilatory efficiency
Time Frame: 1 week per group
VE/VCO2 slope
Exercise capacity during cardiopulmonary exercise test
Time Frame: 1 week per group
Exercise time in minutes and seconds
Cardiorespiratory fitness: absolute oxygen uptake
Time Frame: 1 week per group
absolute peak oxygen uptake in L/min
Power output during pedaling
Time Frame: 1 week per group
Power output in watts
Secondary Outcomes
- Respiratory exchange ratio(1 week per group)
- ventilatory equivalent for carbon dioxide(1 week per group)
- End-tidal partial pressure of oxygen(1 week per group)
- Minute ventilation(1 week per group)
- ventilatory equivalent for oxygen(1 week per group)
- end-tidal partial pressure of carbon dioxide(1 week per group)
- Weight of COVID-19 patients(1 week per group)
- Height of COVID-19 patients(1 week per group)
- Body mass index of COVID-19 patients(1 week per group)