What is the Best Preparation for Embryo Transfer in Cryo Cycles: a Natural Cycle or Light Hormonal Stimulation?

Not Applicable

• Conditions: Infertility
• Interventions: Drug: human menopausal gonadotrophins

• Registration Number: NCT00492934
• Lead Sponsor: University Hospital, Gasthuisberg

Brief Summary

The study investigates if, among women with a regular cycle (between 25 and 45 days), the endometrium is better prepared for the transfer of an embryo that was cryopreserved and if the subsequent embryo implantation rate is higher when the cycle is started with daily, small-dose hormonal injections than in cycles without these daily injections.

Detailed Description

Not available

Study Timeline

• Study Start: 2004-01
• Study First Submitted: 2007-06-26
• Study First Submitted QC: 2007-06-26
• Study First Posted: 2007-06-27
• Primary Completion: 2013-10
• Status Verified: 2014-09
• Last Update Submitted: 2014-09-09
• Last Update Posted: 2014-09-10
• Study Completion: 2014-10

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 300

Inclusion Criteria

• Signed informed consent.
• Women with a regular cycle (between 21 and 35 days).
• Embryos with 50% intact blastomeres after thawing.
• Embryo and endometrium are synchronized.

Exclusion Criteria

• Embryo storage time not longer than 5 years.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
1	human menopausal gonadotrophins	Daily injections with a small dose of gonadotrophins from day 2 of the cycle

Primary Outcome Measures

Name	Time	Method
implantation rate per embryo	15 days after the embryo transfer

Secondary Outcome Measures

Name	Time	Method
thickness of the endometrium	0-2 days before the human chorionic gonadotropin (hCG) injection

Trial Locations

Locations (1)

Leuven University Fertility Center; 🇧🇪 Leuven, Vlaams Brabant, Belgium