Study of Semaglutide, and Cilofexor/Firsocostat, Alone and in Combination, in Adults With Cirrhosis Due to Nonalcoholic Steatohepatitis (NASH)
- Conditions
- Nonalcoholic Steatohepatitis
- Interventions
- Registration Number
- NCT04971785
- Lead Sponsor
- Gilead Sciences
- Brief Summary
The goals of this clinical study are to learn more about the study drugs, semaglutide (SEMA) with the fixed-dose combination (FDC) of cilofexor/firsocostat (CILO/FIR), and understand whether they cause fibrosis improvement and Nonalcoholic Steatohepatitis (NASH) resolution in participants with cirrhosis due to NASH.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 457
-
Liver biopsy consistent with cirrhosis (F4) due to nonalcoholic steatohepatitis (NASH) in the opinion of the central reader. In individuals who have never had a liver biopsy, a screening liver biopsy may be performed.
-
Screening laboratory parameters as determined by the study central laboratory:
- Estimated glomerular filtration rate (eGFR) ≥ 30 mL/min/1.73m^2, as calculated by the Modification of Diet in Renal Disease (MDRD) equation.
- HbA1c ≤ 10%
- International normalized ratio (INR) ≤ 1.4, unless due to therapeutic anticoagulation
- Platelet count ≥ 125,000/uL
- Alanine aminotransferase (ALT) < 5 x ULN
- Serum albumin ≥ 3.5 g/dL
- Serum alkaline phosphatase (ALP) ≤ 2 x ULN
-
Body mass index (BMI) ≥ 23 kg/m^2 at screening.
Key
-
Prior history of decompensated liver disease, including ascites, hepatic encephalopathy (HE), or variceal bleeding.
-
Child-Pugh (CP) score > 6 at screening, unless due to an alternative etiology such as Gilbert's syndrome or therapeutic anticoagulation.
-
Model for End-stage Liver Disease (MELD) score > 12 at screening, unless due to an alternative etiology such as therapeutic anticoagulation.
-
Other causes of liver disease based on medical history and/or central reader review of liver histology, including but not limited to: alcoholic liver disease, autoimmune disorders (eg, primary biliary cholangitis, primary sclerosing cholangitis, autoimmune hepatitis), drug-induced hepatotoxicity, Wilson disease, clinically significant iron overload, or alpha-1-antitrypsin deficiency.
-
Chronic hepatitis B virus (HBV) infection (HBsAg positive), or Chronic hepatitis C virus (HCV) infection (HCV antibody and HCV ribonucleic acid (RNA) positive). Individuals cured of HCV infection less than 2 years prior to the screening visit are not eligible.
-
History of liver transplantation.
-
Current or prior history of hepatocellular carcinoma (HCC).
-
Men who habitually drink greater than 21 units/week of alcohol or women who habitually drink greater than 14 units/week of alcohol (1 unit is equivalent to 12 ounce (oz)/360 mL of beer, a 4 oz/120 mL glass of wine, or 1 oz/30 mL of hard liquor).
- For individuals on vitamin E regimen ≥ 800 IU/day, or pioglitazone, dose must be stable, in the opinion of the investigator for at least 180 days prior to the historical or screening liver biopsy.
- For individuals on medications for diabetes, dose must be stable, in the opinion of the investigator, for at least 90 days prior to the historical or screening liver biopsy.
-
History of type 1 diabetes.
-
Treatment with a glucagon-like peptide-1 receptor agonist (GLP-1 RA) in the period from 90 days prior to the screening visit and for individuals with a qualifying historical liver biopsy, for 90 days prior to the date of the historical liver biopsy.
-
For individuals who have not completed a series of an authorized coronavirus disease 2019 (COVID-19) vaccination regimen prior to screening, a positive result for COVID-19 on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reverse transcriptase-polymerase chain reaction (RT-PCR) test.
Note: Other protocol defined Inclusion/Exclusion criteria may apply.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description SEMA + CILO/FIR FDC Cilofexor (CILO)/Firsocostat (FIR) Participants will receive semaglutide (SEMA) 0.24-2.4 mg once weekly (dose escalation every 4 weeks) and fixed-dose combination (FDC) of cilofexor and firsocostat (CILO/FIR 30 mg/20 mg) once daily for 72 weeks PTM SEMA + PTM CILO/FIR PTM SEMA PTM Semaglutide once weekly and PTM CILO/FIR once daily for 72 weeks SEMA + Placebo-To-Match (PTM) CILO/FIR Semaglutide (SEMA) Participants will receive SEMA 0.24-2.4 mg once weekly (dose escalation every 4 weeks) and PTM CILO/FIR administered once daily for 72 weeks SEMA + Placebo-To-Match (PTM) CILO/FIR PTM CILO/FIR Participants will receive SEMA 0.24-2.4 mg once weekly (dose escalation every 4 weeks) and PTM CILO/FIR administered once daily for 72 weeks SEMA + CILO/FIR FDC Semaglutide (SEMA) Participants will receive semaglutide (SEMA) 0.24-2.4 mg once weekly (dose escalation every 4 weeks) and fixed-dose combination (FDC) of cilofexor and firsocostat (CILO/FIR 30 mg/20 mg) once daily for 72 weeks PTM SEMA + PTM CILO/FIR PTM CILO/FIR PTM Semaglutide once weekly and PTM CILO/FIR once daily for 72 weeks PTM SEMA + CILO/FIR FDC Cilofexor (CILO)/Firsocostat (FIR) PTM Semaglutide once weekly and CILO/FIR 30 mg/20 mg FDC administered once daily for 72 weeks PTM SEMA + CILO/FIR FDC PTM SEMA PTM Semaglutide once weekly and CILO/FIR 30 mg/20 mg FDC administered once daily for 72 weeks
- Primary Outcome Measures
Name Time Method Percentage of Participants Who Achieve ≥ 1-Stage Improvement in Fibrosis According to the NASH Clinical Research Network (CRN) Classification Without Worsening of NASH in Participants Treated With SEMA + CILO/FIR Versus Placebo Week 72 Worsening of NASH is defined as a ≥ 1-point increase in hepatocellular ballooning or lobular inflammation.
- Secondary Outcome Measures
Name Time Method Percentage of Participants With NASH Resolution In Participants Treated With SEMA+CILO/FIR Versus CILO/FIR Alone Week 72 Percentage of Participants Who Achieve ≥1-Stage Improvement in Fibrosis (According to the NASH CRN Classification) Without Worsening of NASH in Participants Treated With SEMA+CILO/FIR Versus SEMA Alone Week 72 Worsening of NASH is defined as a ≥ 1-point increase in hepatocellular ballooning or lobular inflammation.
Percentage of Participants With NASH Resolution in Participants Treated with SEMA+CILO/FIR Versus Placebo Week 72 NASH resolution is defined as lobular inflammation of 0 or 1 and hepatocellular ballooning of 0.
Trial Locations
- Locations (229)
Charter Research
🇺🇸Winter Park, Florida, United States
Mercy Medical Center
🇺🇸Baltimore, Maryland, United States
Rush University Medical Group - Department of Hepatology
🇺🇸Chicago, Illinois, United States
VA Caribbean Healthcare System
🇵🇷San Juan, Puerto Rico
Sierra Clinical Research
🇺🇸Las Vegas, Nevada, United States
Schiff Center for Liver Diseases/ University of Miami
🇺🇸Miami, Florida, United States
ProLive Medical Research, Corp
🇺🇸Miami, Florida, United States
Liver Specialists of Texas
🇺🇸Houston, Texas, United States
Houston Research Institute
🇺🇸Houston, Texas, United States
Precision Research Institute
🇺🇸San Diego, California, United States
Medical Associates Research Group
🇺🇸San Diego, California, United States
Quest Clinical Research
🇺🇸San Francisco, California, United States
University of California, San Francisco - Liver Clinic
🇺🇸San Francisco, California, United States
American Research Corporation at the Texas Liver Institute
🇺🇸San Antonio, Texas, United States
Diabetes and Glandular Disease Clinic, P.A.
🇺🇸San Antonio, Texas, United States
Pinnacle Clinical Research, LLC
🇺🇸San Antonio, Texas, United States
University of Utah Hospital
🇺🇸Salt Lake City, Utah, United States
Henry Ford Health System
🇺🇸Detroit, Michigan, United States
The Institution For Liver Health dba Arizona Liver Health
🇺🇸Tucson, Arizona, United States
Kaiser Permanente Los Angeles Medical Center
🇺🇸Los Angeles, California, United States
University of California, San Diego - Altman Clinical and Translational Research Institute
🇺🇸La Jolla, California, United States
Adobe Clinical Research, LLC
🇺🇸Tucson, Arizona, United States
Knowledge Research Center
🇺🇸Orange, California, United States
Cadena Care Institute, LLC
🇺🇸Poway, California, United States
Research and Education Inc.
🇺🇸San Diego, California, United States
Biopharma Informatic, LLC
🇺🇸McAllen, Texas, United States
Southwest General Healthcare Center
🇺🇸Fort Myers, Florida, United States
Indago Research and Health Center, Inc.
🇺🇸Hialeah, Florida, United States
TriWest Research Associates, LLC
🇺🇸San Diego, California, United States
United Medical Doctors
🇺🇸Murrieta, California, United States
Encore Borland-Groover Clinical Research
🇺🇸Jacksonville, Florida, United States
Evolution Clinical Research, INC
🇺🇸Hialeah Gardens, Florida, United States
Synergy Healthcare
🇺🇸Bradenton, Florida, United States
Hawthorn Medical Associates
🇺🇸South Dartmouth, Massachusetts, United States
Covenant Metabolic Specialists, LLC
🇺🇸Sarasota, Florida, United States
Ocean Blue Medical Research Center, Inc
🇺🇸Miami Springs, Florida, United States
Gastroenterology Group of Naples
🇺🇸Naples, Florida, United States
New Generation of Medical Research
🇺🇸Hialeah, Florida, United States
Florida Medical Clinic, LLC
🇺🇸Zephyrhills, Florida, United States
UF Health Jacksonville-Gastroenterology Emerson
🇺🇸Jacksonville, Florida, United States
Sunbright Health Medical Center
🇺🇸Homestead, Florida, United States
Advanced Pharma CR, LLC
🇺🇸Miami, Florida, United States
Century Research, LLC
🇺🇸Miami, Florida, United States
Ocala GI Research
🇺🇸Ocala, Florida, United States
Kansas Medical Clinic PA
🇺🇸Topeka, Kansas, United States
Beth Israel Deaconess Medical Center
🇺🇸Boston, Massachusetts, United States
New York University Langone Health
🇺🇸New York, New York, United States
Northwell Health Center for Liver Diseases
🇺🇸Manhasset, New York, United States
Internal Medicine Digestive and Liver Diseases Clinical Trials
🇺🇸Dallas, Texas, United States
University of Pittsburgh Medical Center
🇺🇸Pittsburgh, Pennsylvania, United States
Velocity Clinical Research - Providence
🇺🇸East Greenwich, Rhode Island, United States
South Texas Research Institute
🇺🇸Edinburg, Texas, United States
Digestive Health Research of North Texas
🇺🇸Wichita Falls, Texas, United States
Intermountain Medical Center
🇺🇸Murray, Utah, United States
Virginia Mason
🇺🇸Seattle, Washington, United States
The University Of Vermont Medical Center
🇺🇸Burlington, Vermont, United States
Monash Health, Monash Medical Centre (Clayton)
🇦🇺Clayton, Victoria, Australia
Centre Hospitalier Universitaire Limoges
🇫🇷Limoges, France
Centre de Recherche du Centre Hospitalier de I'Universite de Montreal (CRCHUM)
🇨🇦Montreal, Canada
Liver Institute Northwest
🇺🇸Seattle, Washington, United States
Flinders Medical Centre
🇦🇺Adelaide, South Australia, Australia
McMaster University Medical Center
🇨🇦Hamilton, Canada
Centre Hospitalier Regional Universitaire de Tours - Hopital Trousseau
🇫🇷Chambray-les-Tours, France
Royal Brisbane and Women's Hospital
🇦🇺Herston, Queensland, Australia
Toronto Digestive Disease Associates Specialty Research
🇨🇦Vanghan, Canada
Westmead Hospital
🇦🇺Westmead, New South Wales, Australia
Eastern Health, Box Hill Hospital
🇦🇺Box Hill, Victoria, Australia
Digestive and Liver Disease Specialists
🇺🇸Norfolk, Virginia, United States
London Health Sciences Centre - University Hospital
🇨🇦London, Canada
Toronto Liver Centre
🇨🇦Toronto, Canada
CHU Amiens Picardie
🇫🇷Amiens, France
Wlliam Osler Health System - Brampton Civic Hospital
🇨🇦Brampton, Canada
Fukui-ken Saiseikai Hospital
🇯🇵Fukui, Japan
Japanese Red Cross Masashino Hospital
🇯🇵Musashino-city, Japan
Hopitaux de Paris - Hopital Cochin
🇫🇷Paris, France
FDI Clinical Research
🇵🇷San Juan, Puerto Rico
Hospital Germans Trias i Pujol
🇪🇸Badalona, Barcelona, Spain
Ehime University Hospital
🇯🇵Toon-Shi, Japan
Hospital General Universiatrio Gregorio Maranon
🇪🇸Madrid, Spain
Hospital Universitario Puerta de Hierro-Majadahonda
🇪🇸Majadahonda, Spain
Hospital del Mar
🇪🇸Barcelona, Spain
Hospital Universitario Marques de Valdecilla
🇪🇸Santander, Spain
Hospital Clinico Universitario de Santiago
🇪🇸Santiago De Compostella, Spain
Hospital Universitario Virgin del Rocio
🇪🇸Sevilla, Spain
University of Alabama at Birmingham Hospital
🇺🇸Birmingham, Alabama, United States
Mayo Clinic
🇺🇸Rochester, Minnesota, United States
Toronto General Hospital - University Health Network
🇨🇦Toronto, Canada
(G.I.R.I.) Gastrointestinal Research Institute
🇨🇦Vancouver, Canada
Centre Hospitalier Universitaire de Nice - Hopital L'archet
🇫🇷Nice, France
Hopital Brabois Adultes - CHU de Nancy
🇫🇷Vandoeuvre les Nancy, France
Saga University Hospital
🇯🇵Saga-shi, Japan
Saiseikai Suita Hospital
🇯🇵Suita, Japan
Yokohama City University Hospital
🇯🇵Yokohama-shi, Japan
Complejo Hospitalario de Pontevedra
🇪🇸Pontevedra, Spain
Velocity Clinical Research, Salt Lake City
🇺🇸West Jordan, Utah, United States
University of Colorado Anschutz Medical Campus
🇺🇸Aurora, Colorado, United States
Walter Reed National Military Medical Center
🇺🇸Bethesda, Maryland, United States
Keck Medical Center of USC Healthcare Consultation II
🇺🇸Los Angeles, California, United States
California Liver Research Institute
🇺🇸Pasadena, California, United States
Palmtree Clinical Research, Inc.
🇺🇸Palm Springs, California, United States
Gastrointestinal (GI) Specialists of Georgia
🇺🇸Marietta, Georgia, United States
Iowa Digestive Disease Center, PC
🇺🇸Clive, Iowa, United States
CHU de Grenoble
🇫🇷Grenoble Cedex 9, France
Velocity Clinical Research, Hallandale Beach
🇺🇸Hallandale Beach, Florida, United States
San Jose Gastroenterology at One Health
🇺🇸San Jose, California, United States
Southeast Clinical Research LLC
🇺🇸Dalton, Georgia, United States
G+C Research Group
🇺🇸Miami, Florida, United States
Advanced Medical Research Center
🇺🇸Port Orange, Florida, United States
Allied Health Clinical Research Organization, LLC
🇺🇸Freehold, New Jersey, United States
Digestive Research Alliance of Michigan
🇺🇸South Bend, Indiana, United States
Royal Perth Hospital
🇦🇺Perth, Western Australia, Australia
Centre Hosptitalier Universitaire d'Angers
🇫🇷Angers, France
Hopital Saint Joseph
🇫🇷Marseille, France
Sapporo-Kosei General Hospital
🇯🇵Sapporo-shi, Japan
Hopital Universitaire Pitie Salpetriere
🇫🇷Paris, France
Yamagata University Hospital
🇯🇵Yamagata, Japan
University Hospital, Kyoto Prefectural University of Medicine
🇯🇵Kyoto, Japan
Digestive Health Specialists
🇺🇸Dothan, Alabama, United States
Arizona Health Research
🇺🇸Chandler, Arizona, United States
The Institute for Liver Health DBA Arizona Liver Health
🇺🇸Peoria, Arizona, United States
Gastrointestinal Alliance - Sun City
🇺🇸Sun City, Arizona, United States
Arkansas Diagnostic Center
🇺🇸Little Rock, Arkansas, United States
ARCare Center for Clinical Research
🇺🇸Little Rock, Arkansas, United States
Arkansas Gastroenterology
🇺🇸North Little Rock, Arkansas, United States
University of California, San Francisco - Fresno
🇺🇸Fresno, California, United States
Inland Empire Clinical Trials
🇺🇸Rialto, California, United States
Digestive Health Research of Southern California
🇺🇸Long Beach, California, United States
Gastro Care Institute (Fibroscan)
🇺🇸Lancaster, California, United States
Southern California Research Center
🇺🇸Coronado, California, United States
Stanford Medicine Outpatient Center
🇺🇸Redwood City, California, United States
Nature Coast Clinical Research
🇺🇸Inverness, Florida, United States
Excel Medical Clinical Trials, LLC
🇺🇸Boca Raton, Florida, United States
South Denver Gastroenterology
🇺🇸Englewood, Colorado, United States
Maya Research Center
🇺🇸Hialeah, Florida, United States
Florida Research Institute
🇺🇸Lakewood Ranch, Florida, United States
Advanced Research Institute, Inc.
🇺🇸New Port Richey, Florida, United States
International Medical Investigational Centers, Inc.
🇺🇸Miami, Florida, United States
Progressive Medical Research
🇺🇸Port Orange, Florida, United States
Indiana University Health Enterprise Clinical Research Operations
🇺🇸Indianapolis, Indiana, United States
Gastroenterology Health Partners, PLLC
🇺🇸New Albany, Indiana, United States
University of Iowa Hospitals and Clinics
🇺🇸Iowa City, Iowa, United States
GI Alliance
🇺🇸Webster, Texas, United States
Combined Gastro Research, LLC
🇺🇸Lafayette, Louisiana, United States
Delta Research Partners
🇺🇸Monroe, Louisiana, United States
Louisiana Research Center, LLC
🇺🇸Shreveport, Louisiana, United States
Greater Boston Gastroenterology
🇺🇸Framingham, Massachusetts, United States
Woodholme Gastroenterology Associates
🇺🇸Glen Burnie, Maryland, United States
Clinical Research Institute of Michigan, LLC
🇺🇸Chesterfield, Michigan, United States
Gastroenterology Associates of Western Michigan, PLC d.b.a. West Michigan Clinical Research Center
🇺🇸Wyoming, Michigan, United States
Huron Gastroenterology Associates
🇺🇸Ypsilanti, Michigan, United States
Digestive Disease Research
🇺🇸Florham Park, New Jersey, United States
Clinical Research Professionals
🇺🇸Chesterfield, Missouri, United States
Southern Therapy and Advanced Research
🇺🇸Jackson, Mississippi, United States
GI Associates Research
🇺🇸Columbia, Missouri, United States
Rutgers New Jersey Medical School
🇺🇸Newark, New Jersey, United States
Mount Sinai Medical Center
🇺🇸New York, New York, United States
Liver Clinic (study visits, Fibroscan): Columbia University Irving Medical Center / NewYork Presbyterian Hospital
🇺🇸New York, New York, United States
The New York - Presbyterian Hospital
🇺🇸New York, New York, United States
Asheville Gastroenterology, a Division of Digestive Health Partners, PA
🇺🇸Asheville, North Carolina, United States
Atrium Health Transplant and Center for Liver Disease
🇺🇸Charlotte, North Carolina, United States
Coastal Research Institute
🇺🇸Fayetteville, North Carolina, United States
Charlotte Gastroenterology & Hepatology, PLLC
🇺🇸Charlotte, North Carolina, United States
Lucas Research, Inc.
🇺🇸Morehead City, North Carolina, United States
Carolina's GI Research, LLC
🇺🇸Raleigh, North Carolina, United States
Optimed Research
🇺🇸Columbus, Ohio, United States
DSI Research
🇺🇸Springboro, Ohio, United States
Options Health Research, LLC
🇺🇸Tulsa, Oklahoma, United States
Clinical Research Institute of Ohio, LLC
🇺🇸Westlake, Ohio, United States
University Gastroenterology
🇺🇸Providence, Rhode Island, United States
Columbia Digestive Health Research
🇺🇸Columbia, South Carolina, United States
Velocity Clinical Research, Spartanburg
🇺🇸Spartanburg, South Carolina, United States
Digestive Disease Research Center
🇺🇸Greenwood, South Carolina, United States
Wake Research - ClinsSearch, LLC
🇺🇸Chattanooga, Tennessee, United States
Gastrointestinal Associates of Northeast Tennessee
🇺🇸Johnson City, Tennessee, United States
Texas Clinical Research Institute
🇺🇸Arlington, Texas, United States
Pinnacle Clinical Research
🇺🇸Georgetown, Texas, United States
Quality Medical Research, PLLC
🇺🇸Nashville, Tennessee, United States
The Liver Institute at Methodist Dallas Medical Center
🇺🇸Dallas, Texas, United States
Soma Clinical Trials, LLC
🇺🇸Denison, Texas, United States
Houston Methodist Hospital
🇺🇸Houston, Texas, United States
DHR Health Institute for Research and Development Cancer Research Center
🇺🇸Edinburg, Texas, United States
Texas Digestive Specialists
🇺🇸Harlingen, Texas, United States
Liver Associates of Texas, P.A.
🇺🇸Houston, Texas, United States
Impact Research Institute
🇺🇸Waco, Texas, United States
BioStar Clinical Research Group Inc.
🇺🇸Katy, Texas, United States
Digestive System Healthcare
🇺🇸Pasadena, Texas, United States
University of Virginia Medical Center
🇺🇸Charlottesville, Virginia, United States
Manassas Clinical Research Center
🇺🇸Manassas, Virginia, United States
Liverpool Hospital
🇦🇺Liverpool, New South Wales, Australia
University of Calgary Liver Unit - Heritage Medical Research Clinic
🇨🇦Calgary, Canada
Chronic Viral Illness Service, Royal Victoria Hospital, McGill University Health Centre (MUHC)
🇨🇦Montreal, Canada
Gordon and Leslie Diamond Health Care Centre, Vancouver General Hospital, UBC Division of Gastroenterology
🇨🇦Vancouver, Canada
Hopital Beaujon
🇫🇷Pessac, France
Hopital Henri Mondor
🇫🇷Creteil, France
Hopital Claude Huriez
🇫🇷Lille Cedex, France
Hopital Rangueil
🇫🇷Toulouse, France
Hopital de la Croix-Rousse
🇫🇷Lyon, France
CHU Rennes Pontchaillou
🇫🇷Rennes, France
Centre Hospitalier Universitarie de Montpellier - Hospital Saint-Eloi
🇫🇷Montpellier, France
Juntendo University Shizouka Hospital
🇯🇵Izunokuni, Japan
Osaka City University Hospital
🇯🇵Osaka, Japan
Federation of National Public Service Personnel Mutual Aid Associations Toranomon Hospital
🇯🇵Tokyo, Japan
Latin Clinical Trial Center
🇵🇷San Juan, Puerto Rico
Hospital Universitario Torrecardenas
🇪🇸Almeria, Spain
Hospital Universitario Ramon y Cajal
🇪🇸Madrid, Spain
Hospital Clinic De Barcelona
🇪🇸Barcelona, Spain
Hospital Universitari Vall d'Hebron
🇪🇸Barcelona, Spain
Hospital Universitario La Paz Edificio de Malemidad
🇪🇸Madrid, Spain
Consorcio Hospital General Universitario de Valencia
🇪🇸Valencia, Spain
Hospital Universitario y Politecnlo la Fe
🇪🇸Valencia, Spain
Hospital Clinico Universitario de Valladolid
🇪🇸Valladolid, Spain
Tandem Clinical Research GI, LLC
🇺🇸Marrero, Louisiana, United States
North Alabama Health Research, LLC
🇺🇸Madison, Alabama, United States
GI Alliance (Patients Seen, IP Shipment & Fibroscan)
🇺🇸San Marcos, Texas, United States
Northeast GI Research Division
🇺🇸Concord, North Carolina, United States
Hopital Haut Leveque
🇫🇷Pessac Cedex, France
University of California, Davis Medical Center
🇺🇸Sacramento, California, United States
Yale Center for Clinical Investigation, Church Street Research Unit
🇺🇸New Haven, Connecticut, United States
Michigan Medicine - University of Michigan
🇺🇸Ann Arbor, Michigan, United States
Kansas City Research Institute
🇺🇸Kansas City, Missouri, United States
Medical University of South Carolina
🇺🇸Charleston, South Carolina, United States
University of Florida Hepatology Research at the Clinical and Translational Research Building
🇺🇸Gainesville, Florida, United States
Oschner Clinic Foundation
🇺🇸New Orleans, Louisiana, United States
Tulane University Health Sciences Center
🇺🇸New Orleans, Louisiana, United States
Bon Secours Richmond Community Hospital, Inc. d/b/a Bon Secours Liver Institute of Richmond
🇺🇸Richmond, Virginia, United States
Virginia Commonwealth University Health Clinical Research Services Unit
🇺🇸Richmond, Virginia, United States
Center for Research at Southwest Gastroenterology Associates, PC
🇺🇸Albuquerque, New Mexico, United States
University of Rochester Medical Center
🇺🇸Rochester, New York, United States
University of Kansas Medical Center
🇺🇸Kansas City, Kansas, United States