Computed Tomography Angiography Accuracy in Brain Death Diagnosis
- Conditions
- Brain Death
- Registration Number
- NCT02045407
- Lead Sponsor
- Sergio Brasil, MD MSc
- Brief Summary
The purpose of this study is to assess the reliability of computed tomography angiography (CTA) to diagnose brain death, face of several conditions that make impossible to define such diagnosis using clinical criteria exclusively.
- Detailed Description
Critically ill patients, presenting Glasgow Coma Score 5 or lower, will be submitted to the Computed Tomography Angiography (CTA) of the skull assessment, and follow a clinical evaluation for brain death, additionally, transcranial Doppler would be applied as the gold standard for brain death.
We will exclude patients whose do not can be submitted to contrast injection, or if a brain death clinical evaluation has been performed prior the CTA.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 106
- Individuals of any age or sex with brain death suspicion raised, before clinical test.
- Comatose patients presenting Glasgow Coma Score as or under 5 points, under sedative agents or not.
- Brain dead patients clinically confirmed.
- Contraindications to the use of contrast medium (renal failure or allergy).
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Assess the presence or absence of contrast medium filling of the intracranial vessels in comatose patients. 1 year After excluding confounding factors, we will submit comatose patients to CTA. Immediately after the exam, we will perform clinical evaluation for brain death and calculate CTA sensibility and specificity for this diagnosis. Time between these two interventions will be measured.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Hospital das Clínicas da Faculdade de Medicina da USP.
🇧🇷São Paulo, Brazil