The Effect of Periodontal Treatment on Psoriasis

Not Applicable

Completed

• Conditions: Periodontal Diseases
• Interventions: Other: Psoriatic measurements; Other: Non-surgical periodontal treatment; Other: saliva samples

• Registration Number: NCT03939936
• Lead Sponsor: Ozge Gokturk

Brief Summary

There is a relationship between psoriasis and periodontal disease. This relationship may be double-sided.

Detailed Description

The aim of this randomized controlled clinical study was to determine the effect of non-surgical mechanical periodontal treatment on psoriasis. The study population consisted of 92 periodontitis patients with psoriasis who had untreated periodontal disease. Two randomized groups were formed from these patients. Immediate periodontal treatment (test group, n = 46) and delayed periodontal treatment (control group, n = 46). Clinical periodontal measures, saliva interleukin 2, interleukin 6 and secretory immunoglobulin A levels and PASI scores were performed at baseline and 8th week in control and test group.

Study Timeline

• Study Start: 2017-05-01
• Primary Completion: 2018-01-30
• Study Completion: 2018-02-15
• Study First Submitted: 2019-04-26
• Status Verified: 2019-05
• Study First Submitted QC: 2019-05-03
• Study First Posted: 2019-05-07
• Last Update Submitted: 2019-05-07
• Last Update Posted: 2019-05-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 92

Inclusion Criteria

• the presence at least 20 remaining teeth,
• the presence of Stage I or Stage II Periodontitis,
• the presence of diagnosed psoriasis.

Exclusion Criteria

• patients who had the immune-inflammatory disease and require antibiotic prophylaxis,
• patients who received periodontal treatment prior to 6 months,
• women who were breastfeeding or pregnant,
• patients using medicines such as antibiotics, anti-inflammatory drugs, immune-suppressants.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Test Group	Psoriatic measurements	Psoriatic measurements and saliva samples were taken from periodontal disease patients before treatment and after 8 weeks. Intervention: Non-surgical periodontal treatment was performed and the Psoriasis Area and Severity Index (PASI) was filled, saliva samples were taken.
Test Group	Non-surgical periodontal treatment	Psoriatic measurements and saliva samples were taken from periodontal disease patients before treatment and after 8 weeks. Intervention: Non-surgical periodontal treatment was performed and the Psoriasis Area and Severity Index (PASI) was filled, saliva samples were taken.
Test Group	saliva samples	Psoriatic measurements and saliva samples were taken from periodontal disease patients before treatment and after 8 weeks. Intervention: Non-surgical periodontal treatment was performed and the Psoriasis Area and Severity Index (PASI) was filled, saliva samples were taken.
Control Group	Psoriatic measurements	Psoriatic measurements and saliva samples were taken from periodontal disease patients at the baseline and after 8 weeks without the periodontal treatment. Intervention: Psoriasis Area and Severity Index (PASI) was filled, saliva samples were taken.
Control Group	saliva samples	Psoriatic measurements and saliva samples were taken from periodontal disease patients at the baseline and after 8 weeks without the periodontal treatment. Intervention: Psoriasis Area and Severity Index (PASI) was filled, saliva samples were taken.

Primary Outcome Measures

Name	Time	Method
Proinflammatory cytokines	Baseline and after 8 weeks	The changes in proinflammatory cytokines levels within 8 weeks. Higher values represent a worse outcome. The decrease in proinflammatory cytokines levels is expected after periodontal treatment.

Secondary Outcome Measures

Name	Time	Method
PASI index	Baseline and after 8 weeks	The changes in PASI index level after periodontal treatment. PASI index was measured for determining the severity of psoriasis disease. Higher values represent a worse outcome. After periodontal treatment, a reduction in PASI index value is expected.
Gingival index	Baseline and after 8 weeks	The changes in gingival index level after periodontal treatment. Gingival index was measured for determining the severity of disease and clinical outcome. Higher values represent a worse outcome. After periodontal treatment, a reduction in gingival index value is expected.

Trial Locations

Locations (1)

Gaziosmanpasa University; 🇹🇷 Tokat, Turkey