Effects of Non-surgical Periodontal Therapy on Inflammatory Markers of Psoriasis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 92
- 试验地点
- 1
- 主要终点
- Proinflammatory cytokines
研究概览
简要总结
There is a relationship between psoriasis and periodontal disease. This relationship may be double-sided.
详细描述
The aim of this randomized controlled clinical study was to determine the effect of non-surgical mechanical periodontal treatment on psoriasis. The study population consisted of 92 periodontitis patients with psoriasis who had untreated periodontal disease. Two randomized groups were formed from these patients. Immediate periodontal treatment (test group, n = 46) and delayed periodontal treatment (control group, n = 46). Clinical periodontal measures, saliva interleukin 2, interleukin 6 and secretory immunoglobulin A levels and PASI scores were performed at baseline and 8th week in control and test group.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •the presence at least 20 remaining teeth,
- •the presence of Stage I or Stage II Periodontitis,
- •the presence of diagnosed psoriasis.
排除标准
- •patients who had the immune-inflammatory disease and require antibiotic prophylaxis,
- •patients who received periodontal treatment prior to 6 months,
- •women who were breastfeeding or pregnant,
- •patients using medicines such as antibiotics, anti-inflammatory drugs, immune-suppressants.
研究组 & 干预措施
Test Group
Psoriatic measurements and saliva samples were taken from periodontal disease patients before treatment and after 8 weeks.
Intervention: Non-surgical periodontal treatment was performed and the Psoriasis Area and Severity Index (PASI) was filled, saliva samples were taken.
干预措施: Psoriatic measurements (Other)
Test Group
Psoriatic measurements and saliva samples were taken from periodontal disease patients before treatment and after 8 weeks.
Intervention: Non-surgical periodontal treatment was performed and the Psoriasis Area and Severity Index (PASI) was filled, saliva samples were taken.
干预措施: Non-surgical periodontal treatment (Other)
Test Group
Psoriatic measurements and saliva samples were taken from periodontal disease patients before treatment and after 8 weeks.
Intervention: Non-surgical periodontal treatment was performed and the Psoriasis Area and Severity Index (PASI) was filled, saliva samples were taken.
干预措施: saliva samples (Other)
Control Group
Psoriatic measurements and saliva samples were taken from periodontal disease patients at the baseline and after 8 weeks without the periodontal treatment.
Intervention: Psoriasis Area and Severity Index (PASI) was filled, saliva samples were taken.
干预措施: Psoriatic measurements (Other)
Control Group
Psoriatic measurements and saliva samples were taken from periodontal disease patients at the baseline and after 8 weeks without the periodontal treatment.
Intervention: Psoriasis Area and Severity Index (PASI) was filled, saliva samples were taken.
干预措施: saliva samples (Other)
结局指标
主要结局
Proinflammatory cytokines
时间窗: Baseline and after 8 weeks
The changes in proinflammatory cytokines levels within 8 weeks. Higher values represent a worse outcome. The decrease in proinflammatory cytokines levels is expected after periodontal treatment.
次要结局
- PASI index(Baseline and after 8 weeks)
- Gingival index(Baseline and after 8 weeks)
研究者
Ozge Gokturk
Principal Investigator
Tokat Gaziosmanpasa University