Can Theta Burst stimulation accelerate re-learning of impaired wrist and hand movements early after stroke?

Completed

Conditions: Topic: Stroke Research Network
Subtopic: Rehabilitation
Disease: Device used, Therapy type
Circulatory System
Stroke

Registration Number: ISRCTN99874413

Lead Sponsor: niversity College London Hospitals NHS Foundation Trust (UK)

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 30

Inclusion Criteria

1. First ever ischaemic stroke (previous transient ischaemic attack [TIA] is not a problem)
2. One to three months post stroke
3. Some movement in the wrist and fingers (wrist extension greater than or equal to 20° and thumb flexion greater than or equal to 10°)
4. English speaking
5. Aged over 18 years of age, either sex

Exclusion Criteria

1. Intracerebral or subarachnoid haemorrhage
2. Large strokes (greater than 50% of the middle cerebral artery [MCA] territory)
3. Increased muscular tone (greater than 2 in the Ashworth scale or not able to let go after grip without using the intact hand)
4. Cardiac pacemaker or intracardiac lines
5. Metallic objects in the head or in the eyes (e.g. clips from surgery, exposure to fast metallic flakes; metal in the mouth/teeth is not a problem)
6. Any history of epilepsy or fits including childhood
7. Inability to consent or comply with the study procedures (cognitive impairment, significant aphasia, visual field defect, or non-English speakers)

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Motor performance, collected during each practice

Secondary Outcome Measures

Name	Time	Method
Standardised tests of the arm and hand function that have been used repeatedly to assess recovery, performed on day 1 and 5:<br>1. Action Research Arm Test (ARAT)<br>2. Jebsen Taylor Hand Test<br>3. 9-Hole Peg Test<br>4. Electrophysiological measures of corticospinal excitability determined by TMS