Reduction of Myocardial Infarction by Preconditioning in Patients With Ruptured Abdominal Aortic Aneurysm
- Conditions
- Abdominal Aortic Aneurysm
- Interventions
- Procedure: Precondition
- Registration Number
- NCT00883363
- Lead Sponsor
- Nikolaj Eldrup
- Brief Summary
Preconditioning in patients treated for elective abdominal aneurysm showed that the rate of perioperative myocardial infarction could be reduced by 80 %(ARR from 27% to 5%). Precondition where performed by 10 minutes of clamping of each iliac arteries before clamping the abdominal aorta. Human studies in cardiac patients have shown promising results with precondition. Instead of clamping arteries they have all performed the procedure by inflating a blood pressure cuff above arterial pressure on a arm.
The investigators want to investigate if preconditioning induced by a blood pressure cuff on a arm can reduce the perioperative rate of myocardial infarction in patients open operated for ruptured abdominal aortic aneurysm.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 200
- Patients with ruptured abdominal aortic aneurysm offered surgery
- Age > 18 years
- Technical inoperable
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Precondition Precondition Induction of precondition at start of operation on a arm
- Primary Outcome Measures
Name Time Method Reduction in myocardial infarction 4 to 5 years
- Secondary Outcome Measures
Name Time Method Improvement in survival Description on inflammatory response 4 to 5 years
Trial Locations
- Locations (1)
Aarhus university hospital skejby department of cardio thoracic and vascular surgery
🇩🇰Aarhus, Region Midt, Denmark