Efficacy of Immunomudulatory Therapy With All-trans Retinoid Acid for Adults With Chronic Immune Thrombocytopenia

Completed

• Conditions: Immune Thrombocytopenic Purpura

• Registration Number: NCT01668615
• Lead Sponsor: First Affiliated Hospital of Suzhou Medical College

Brief Summary

The purpose of this study is to determine whether All-trans retinoic acid (ATRA) are effective in the treatment of refractory idiopathic thrombocytopenic purpura (RITP).

Detailed Description

Idiopathic thrombocytopenic purpura(ITP), an acquired immune disease is characterized by impaired generation of autoantibody-specific platelet. At least 30% adult patients turn into refractory ITP. The pathogenesis of ITP remains to be elucidated. Now ,CD4+ helper cells have been classified as belong to T-helper 1(TH1), T-helper 2(TH2), T-helper17and Regulory T cell(Tregs). All-trans retinoic acid(ATRA) mainly applied in skin disease and acute promyelocytic leukemia. Recently, ATRA is also a immunomodulator which can induce differentiation, proliferation, apoptosis of cells, and immunomudulatory. In the international, the investigators first treat RITP with ATRA. To investigate the therapeutic effects of ATRA on RITP, and using new index in the cells, cytokines and molecular biology of three in-depth study of its mechanism.

Study Timeline

• Study Start: 2011-01
• Study First Submitted: 2012-07-30
• Primary Completion: 2012-08
• Study Completion: 2012-08
• Study First Submitted QC: 2012-08-16
• Study First Posted: 2012-08-20
• Status Verified: 2012-10
• Last Update Submitted: 2012-10-21
• Last Update Posted: 2012-10-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 35

Inclusion Criteria

• Clinical diagnosis of refratory idiopathic thrombocytopenic purpura
• Hormone and immune suppression, splenectomy is invalid

Exclusion Criteria

• Other autoimmune diseases

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

Jiangsu Institute of Hematology; 🇨🇳 Suzhou, Jiangsu, China