Milk and Milk-produce to Counteract the Loss of Muscle Mass and Function in Exercising Older Adults.

Not Applicable

Completed

• Conditions: Sarcopenia
• Interventions: Other: Resistance training

• Registration Number: NCT01883674
• Lead Sponsor: Université de Sherbrooke

Brief Summary

This project evaluates the use of different types of proteins from various food sources after an exercise session, on muscle mass and physical capacity in aged sarcopenic men (who have low muscle mass). Specifically, researchers want to:

* Examine the efficiency of protein intake after exercise on muscle mass and physical abilities;

* Examine the impact of exercise and proteins on blood lipids (LDL cholesterol, HDL cholesterol, total cholesterol and triglycerides);

* Examine the impact of exercise and proteins on liver enzymes;

* Examine the impact of exercise and proteins on a hormone that controls hunger;

* Evaluate the program's impact on the ability of the body to produce energy.

All participants are exercising (resistance training) and ingest one of the 3 different sources of proteins, immediately after training:

* Milk proteins (from milk beverage)

* Essential amino acids (added to a soya beverage)

* No protein (rice beverage - control group)

Our hypothesis is that proteins from milk will induce a gain in muscle mass and physical function equivalent to the essential amino acids (EAA). We anticipate that both milk proteins and EAA will be both superior to control group.

This would represent an interesting finding since milk is more accessible, palatable and cheaper than essential amino acids commercial mix.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-05
• Study First Submitted: 2013-02-07
• Study First Submitted QC: 2013-06-18
• Study First Posted: 2013-06-21
• Primary Completion: 2014-04
• Status Verified: 2014-12
• Study Completion: 2014-12
• Last Update Submitted: 2014-12-01
• Last Update Posted: 2014-12-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 41

Inclusion Criteria

• 65-75 years
• francophone or understanding French
• muscle mass index < 10.75 kg/m2 (Janssen et al, 2004)
• body mass index <30kg/m²
• weight stable (< 2 kg) for 6 mo
• no resistance exercise for 3 years
• controlled blood pressure for at least 6 months

Exclusion Criteria

• major physical disability
• medical treatment influencing metabolism
• statin treatment
• diagnosis or any sign of kidney disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
No protein (control)	Resistance training	This group will do a resistance training + ingestion of the control beverage (no protein, rice beverage)
Milk proteins	Resistance training	This group will do a resistance training + milk proteins (milk beverage)
Essential amino acids (add to soya bvg)	Resistance training	This group will do a resistance training + essential amino acids (added to soya beverage)

Primary Outcome Measures

Name	Time	Method
Muscle mass	At baseline and post intervention (17th week)

Secondary Outcome Measures

Name	Time	Method
Blood markers of inflammation	At baseline and post intervention (17th week)	Plasmatic IL-6 anf TNF-alpha
Relative strength	At baseline and post intervention (17th week)
Plasma creatinine	At baseline, mid (8th week) and post intervention (17th week)	Blood marker on renal function will be assessed to ensure the safety of the supplementation of protein intake on renal function in sarcopenic men.
Blood markers of fatty liver	At baseline and post intervention (17th week)	Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Gamma-glutamyltransferase (GGT) and Alkaline phosphatase (ALP).
extracellular HSP72	At baseline and post intervention (17th week)
Plasma Lipid profile	At baseline and post intervention (17th week)	Apolipoproteins (Apo-AI, Apo-AII, Apo-B); Total cholesterol, HDL, LDL and triglycerides.

Trial Locations

Locations (1)

Centre de recherche sur le vieillissement; 🇨🇦 Sherbrooke, Quebec, Canada