Exercise as a Strategy to Treat Cognitive Dysfunction in Persons With Multiple Sclerosis

Phase 1

Completed

• Conditions: Multiple Sclerosis
• Interventions: Behavioral: stretching; Behavioral: exercise

• Registration Number: NCT01219647
• Lead Sponsor: University of California, Los Angeles

Brief Summary

Many persons with Multiple Sclerosis ( MS) have problems with memory and thinking.Exercise has been shown to improve memory and thinking in persons with diseases such as Alzheimer's. This study will investigate whether a program of aerobic exercise can improve memory and thinking in persons with MS

Detailed Description

Persons with Multiple Sclerosis(MS)will be screened for eligibility and randomized to a protocol with two intervention arms. One group will have aerobic training on a recumbent cross trainer three times a week for 20-30 minutes/session. The other group will participate in stretching exercises at the same frequency and intensity.Total training time will be six months.Outcome measures will include tests of memory and thinking, and fitness measures.

Study Timeline

• Study Start: 2010-07
• Study First Submitted: 2010-10-08
• Study First Submitted QC: 2010-10-12
• Study First Posted: 2010-10-13
• Primary Completion: 2014-08
• Study Completion: 2014-08
• Status Verified: 2014-12
• Last Update Submitted: 2014-12-05
• Last Update Posted: 2014-12-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 35

Inclusion Criteria

• Clinical Diagnosis of MS Complaints of cognitive problems Able to ride a recumbent cross trainer

Exclusion Criteria

• Cardiopulmonary or structural disease that would limit ability to participate in exercise training On treatment with chemotherapy or natalizumab Screening score of >50 on PASAT

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
stretching	stretching	Subjects will particiate in supervised stretching at same frauency, duration and intensity of aerobic exericse arm
aerobic exercise	exercise	Subjects will train on a recumbent cross trainer 20-30 minutes/session for three times/week for six months under supervision of a fitness specialist

Primary Outcome Measures

Name	Time	Method
Paced Auditory Serial Addition Test (PASAT)	36 weeks	test of attention and information processing

Secondary Outcome Measures

Name	Time	Method
Symbol Digit Modalities Test (SDMT)	36 weeks	test of attention and information processing
VO2 max	36 weeks	measure of fitness via oxygen consumption and use
Long latency cognitive event related potentials ( LLCERP)	36 weeks	electrophysiologic tests of information processing

Trial Locations

Locations (2)

CAl State University at Northridge; 🇺🇸 Northridge, California, United States

UCalifornia at Los Angeles; 🇺🇸 Los Angeles, California, United States