Exercise as a Strategy to Treat Cognitive Dysfunction in Persons With Multiple Sclerosis
Overview
- Phase
- Phase 1
- Intervention
- Not specified
- Conditions
- Multiple Sclerosis
- Sponsor
- University of California, Los Angeles
- Enrollment
- 35
- Locations
- 2
- Primary Endpoint
- Paced Auditory Serial Addition Test (PASAT)
- Status
- Completed
- Last Updated
- 11 years ago
Overview
Brief Summary
Many persons with Multiple Sclerosis ( MS) have problems with memory and thinking.Exercise has been shown to improve memory and thinking in persons with diseases such as Alzheimer's. This study will investigate whether a program of aerobic exercise can improve memory and thinking in persons with MS
Detailed Description
Persons with Multiple Sclerosis(MS)will be screened for eligibility and randomized to a protocol with two intervention arms. One group will have aerobic training on a recumbent cross trainer three times a week for 20-30 minutes/session. The other group will participate in stretching exercises at the same frequency and intensity.Total training time will be six months.Outcome measures will include tests of memory and thinking, and fitness measures.
Investigators
Barbara Giesser
Clincial Profesor of Neurology
University of California, Los Angeles
Eligibility Criteria
Inclusion Criteria
- •Clinical Diagnosis of MS Complaints of cognitive problems Able to ride a recumbent cross trainer
Exclusion Criteria
- •Cardiopulmonary or structural disease that would limit ability to participate in exercise training On treatment with chemotherapy or natalizumab Screening score of \>50 on PASAT
Outcomes
Primary Outcomes
Paced Auditory Serial Addition Test (PASAT)
Time Frame: 36 weeks
test of attention and information processing
Secondary Outcomes
- Symbol Digit Modalities Test (SDMT)(36 weeks)
- Long latency cognitive event related potentials ( LLCERP)(36 weeks)
- VO2 max(36 weeks)