Skip to main content
Clinical Trials/NCT06069986
NCT06069986
Recruiting
Not Applicable

On-pump Versus Off-pump Coronary Artery Bypass Grafting , Short Term Outcomes , Sohag Experience

Sohag University1 site in 1 country120 target enrollmentJuly 10, 2023

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Coronary Artery Disease
Sponsor
Sohag University
Enrollment
120
Locations
1
Primary Endpoint
comparison to declare the rate of morbidity and mortality using both techniques on pump and off pump in CABG and which is better in short term outcomes
Status
Recruiting
Last Updated
2 years ago

Overview

Brief Summary

Coronary artery disease (CAD) and its sequlae, such as myocardial infarction, arrhythmia and heart failure, are among the leading causes of death around the world . the durable role of coronary artery bypass grafting (CABG) in the treatment of CAD has long been shown.

Coronary artery bypass grafting (CABG) is a commonly performed surgical procedure for patients with coronary artery disease (CAD), CABG can be performed using either the on-pump or off-pump technique, each with its own advantages and limitations.

On-pump CABG involves the use of CPB which as agold standard for surgical coronary revascularization has led toexcellent results in mortality and complications. On-pump CABG allows the surgeon to temporarily stop the heart and provide perfusion and oxygenation to the body. This technique provides a bloodless and motionless operative field, allowing for precise graft anastomosis. However, the use of CPB is associated with deleterious effects as systemic inflammatory response, hemodilution, and organ dysfunction as dysrhythmia and neurocognitive problems. These factors may adversely affect patients lives specially those with impaired EF, who already have compromised cardiovascular function.

Another technique for CABG is on-pump beating heart CABG (ONBH-CABG) surgery that is relatively novel hybrid approach to coronary artery grafting which aims to stabilize hemodynamic parameters during the operative period. This has specific benefits such as reduced preload alongside the afterload which decreases the oxygen demand of the myocardial tissue

Registry
clinicaltrials.gov
Start Date
July 10, 2023
End Date
July 10, 2024
Last Updated
2 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Ziad Essam Ahmed

assistant lecturer cardithoracic surgery sohag university

Sohag University

Eligibility Criteria

Inclusion Criteria

  • fair and impaired EF

Exclusion Criteria

  • malignancy
  • renal failure on dialysis

Outcomes

Primary Outcomes

comparison to declare the rate of morbidity and mortality using both techniques on pump and off pump in CABG and which is better in short term outcomes

Time Frame: 1 year

which is better in morbidity and mortality, on pump or off pump CABG specially in patients with low ejection fraction (less than 40%)

Study Sites (1)

Loading locations...

Similar Trials