The effect of Glucocorticoid Receptor Polymorphisms and Metabolically Active Genetic Variants on Glucose Metabolism in the Skeletal Muscle

Recruiting

• Conditions: diabetes; insulin resistance; 10018424

• Registration Number: NL-OMON47510
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 447

Inclusion Criteria

Subjects selected from studies 09-3-033; 07-3-028; 04-257; 03-015; 06-3-038;
09-3-039; 11-3-092; 11-2-003; 13-3-058; 13-2-030; 15-3-030; 113003; 153046;
163019; 163052; 173008; 173017; 173021; 173024; 173031; 173037; 183001 and
183006 (n=447).

Exclusion Criteria

NA, these already have been set by the previous studies.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>New study outcome parameter:<br /><br>- profile of GC-polymorphisms<br /><br>- genetic variants influencing energy-metabolism<br /><br><br /><br>Study outcome parameters (already obtained):<br /><br>-Body composition (underwater weighing)<br /><br>-Insulin sensitivity (hyperinsulinemic-euglycemic clamp)<br /><br>-Substrate oxidation (indirect calometry during the clamp)<br /><br>-Skeletal muscle oxidative capacity<br /><br>-VO2max-test<br /><br>-Skeletal muscle lipid accumulation in muscle biopsies.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>NA</p><br>