Effect of dry ziziphus jujube in diabetic overweight or obese subjects

Phase 3

Recruiting

Conditions: Condition 1: Type 2 diabetes. Condition 2: Obesity.
Diabetes mellitus due to underlying condition
Overweight and obesity

Registration Number: IRCT20181210041913N1

Lead Sponsor: Shahid Beheshti University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 44

Inclusion Criteria

Agreement to participate in the study and completing informed consent form
Aged 35-65 years old
The duration of the disease should be between 1 to 10 years
Fasting blood glucose and 2-h blood glucose should be less than 126 and 200 mg / dl, respectively.
Body mass index=25 kg/m2
Patients who take only oral medication (not insulin) to control diabetes.

Exclusion Criteria

having allergy to dry jujube
using of alcohol, opioids, and anti-inflammatory drugs.
using of multi-vitamin mineral supplements, administration of clozapine, theophylline, caffeine, fennetin and tacrin.
Pregnant and lactating Women

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Serum concentrations of blood glucose. Timepoint: Before the intervention and 10 weeks after the intervention. Method of measurement: Enzymatic method.;Serum concentrations of total cholesterol. Timepoint: Before the intervention and 10 weeks after the intervention. Method of measurement: Enzymatic method.;Serum concentrations of triglyceride. Timepoint: Before the intervention and 10 weeks after the intervention. Method of measurement: Enzymatic method.;Low density lipoprotein- cholesterol. Timepoint: Before the intervention and 10 weeks after the intervention. Method of measurement: Enzymatic method.;High density lipoprotein- cholesterol. Timepoint: Before the intervention and 10 weeks after the intervention. Method of measurement: Enzymatic method.

Secondary Outcome Measures

Name	Time	Method
Serum concentration of Insulin. Timepoint: Before the intervention and 10 weeks after the intervention. Method of measurement: ELISA method.;Serum concentration of malondialdehyde. Timepoint: Before the intervention and 10 weeks after the intervention. Method of measurement: Colorimetric method.;Serum concentration of Carboxy-methyl lysine. Timepoint: Before the intervention and 10 weeks after the intervention. Method of measurement: ELISA method.;Serum concentration of Interleukin-6. Timepoint: Before the intervention and 10 weeks after the intervention. Method of measurement: ELISA method.;Serum concentration of hs-CRP. Timepoint: Before the intervention and 10 weeks after the intervention. Method of measurement: ELISA method.;Serum concentration of fructoseamine. Timepoint: Before the intervention and 10 weeks after the intervention. Method of measurement: ELISA method.