NCT00510172Unknown不适用
Migraine Inducing Effects and Changes in Brain Haemodynamics of PGI2
Glostrup University Hospital, Copenhagen1 个研究点 分布在 1 个国家目标入组 12 人开始时间: 2006年12月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Headache and accompanying symptoms. Blood flow velocity in the middle cerebral artery, diameter changes in superficial temporal artery and radial artery.
研究概览
简要总结
We hypothesised that intravenous infusion of PGI2 induced headache or migraine and cranial vasodilatation in migraineurs.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •migraine without aura and healthy apart from that
- •age 18-55 years
- •50-100 kg
- •Secure contraceptives
排除标准
- •Tension Type Headache more than 3 time a month
- •Other primary headaches
- •Medication prior to the study (closer than 4 times plasma halflife)
- •Migraine or headache 5 days prior to study.
- •Hypertension (systolic BP >150 mmHg and/or diastolic BP >100 mmHg).
- •Hypotension (systolic BP <90 mmHg and/or diastolic BP <50 mmHg).
- •Heart-vessel disease of any kind incl cerebrovascular disease.
- •Anamnestic or clinical signs of psychiatric disease or abuse.
- •Anamnestic or clinical signs of disease of any kind relevant for participation in the study.
研究组 & 干预措施
2
Placebo Comparator
Placebo
干预措施: Placebo (Drug)
1
Active Comparator
Active treatment
干预措施: Prostacyclin, PGI2 (Drug)
结局指标
主要结局
Headache and accompanying symptoms. Blood flow velocity in the middle cerebral artery, diameter changes in superficial temporal artery and radial artery.
时间窗: 14 hours
次要结局
- Blood pressure, pulse(100 min)
研究者
研究点 (1)
Loading locations...
相似试验
终止
1 期
PGI2 Induced Headache and Cerebral Haemodynamics in Healthy VolunteersHeadacheMigraineNCT00291395Danish Headache Center12
已完成
不适用
Prostaglandin E2 in Migraine Suffers Without Aura."Migraine-like" HeadacheNCT01384812Troels Wienecke12
已完成
不适用
Headache Inducing Characteristics and Possible Changes in Cerebral Blood Flow After Administration of PGE2HeadacheMigraineNCT00374530Danish Headache Center12
已完成
不适用
Hemodynamic and Headache-Inducing Effect of Intravenous Vasoactive Intestinal Peptide in MigraineursHeadacheVasoactive Intestinal PeptideUltrasonography, Doppler, TranscranialMigraineNCT00272896Danish Headache Center12
终止
不适用
MIBRAIN - Migraine and the Brain: Consequences, Causes, and Vascular InteractionMigraineNCT01803984University Hospital, Bordeaux166