Study on the relationship between pathological tumor regression grade and prognosis of advanced hepatocellular carcinoma after conversion therapy
- Conditions
- hepatocellular carcinoma
- Registration Number
- ChiCTR2400088877
- Lead Sponsor
- West China Hospital, Sichuan University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- Not specified
a. Age between 18 and 65 years (including patients aged 18 years) <br>b. Clinical diagnosis is hepatocellular carcinoma (According to the diagnosis and treatment guidelines for primary liver cancer (2022 edition) diagnostic criteria: HBV or HCV infection or cirrhosis caused by any cause, liver nodules = 2 cm in diameter were found, multi-parameter MRI, dynamic enhanced CT, contrast-enhanced ultrasound or hepatocyte specific contrast agent Gd-EOB-DTPA enhanced MRI showed at least 2 typical features of fast forward and fast out of liver cancer; or the presence of intrahepatic nodules> 2 cm in diameter, as long as one of the above four imaging examinations has typical liver cancer characteristics; serum AFP is elevated, especially continuously elevated, and only one of the above four imaging examinations has typical liver cancer characteristics; liver biopsy is definitely diagnosed as HCC) <br>c. For patients with BCLC stage B or C, the first treatment received by the patient was intervention, molecular-targeted drugs, immunotherapy, systemic chemotherapy, etc., and the lesion could be radical surgical resection under imaging evaluation after treatment.<br>d. Normal or downgraded liver function meeting surgical criteria (Child-Pugh A or screening Child-Pugh B liver function, ICG-R15 <14%, ECOG performance score 0-1) <br>e. Can tolerate surgery under general anesthesia
a. Combined with other malignant tumors<br>b. Patients who did not meet the criteria for conversion surgery after comprehensive treatment, or who did not complete a treatment cycle and withdrew <br>c. The pathological margin after operation did not reach the R0 resection standard<br>d. There are serious functional disorders of heart, brain, lung, kidney and other important organ systems;<br>e. Missing clinicopathological data and uncooperative follow-up.
Study & Design
- Study Type
- Observational study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method pathological tumor regression grade;recurrence-free survival;overall survival;postoperative complication;
- Secondary Outcome Measures
Name Time Method