Remote Ischemic Conditioning in Renal Transplantation - Effect on Immediate and Extended Kidney Graft Functio

Completed

• Conditions: niertransplantatie; Kidney Graft Function; Renal Transplantation

• Registration Number: NL-OMON40158
• Lead Sponsor: anesthesiologie- onderzoeksbureau

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 100

Inclusion Criteria

•Age 18 and above
•Received information, signed consent
•Candidate for kidney transplantation from deceased donor

Exclusion Criteria

•Can't give informed consent
•AV-fistula in the leg opposite the site where the graft will be placed
•Threatening ischemia in the leg

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>he initial rate of plasma creatinine decline and the need for dialysis post<br /><br>transplantation constitute the primary endpoint (DGF). The method for<br /><br>describing the rate of creatinine decline has been established in corporation<br /><br>with a statistician and is based on data from earlier transplanted patients</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Additional endpoints include:<br /><br>1) GFR measured from 24 hours urine collection at day 5 post transplantation as<br /><br>well as 3 and 12 months after transplantation measured from Ioodthalamaat<br /><br>clearance according to standard institutional guidelines,<br /><br>2) urinary and plasma biomarkers of acute kidney injury,<br /><br>3) rejection episodes.<br /><br>Furthermore, we planned to investigate possible mechanisms of<br /><br>ischemia/reperfusion injury and potential, protective effects of rIC by<br /><br>analysing important mediators in renal biopsies, plasma and urine.</p><br>