A Supervised Exercise Program Reduces Fat Mass and Cardiovascular Risk Factors in Patients Awaiting Bariatric Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 18
- 主要终点
- Change from Baseline Cardiorespiratory Fitness at 3 months
研究概览
简要总结
Background: Weight reduction, especially of visceral fat in patients awaiting bariatric surgery (BS), may facilitate the surgical process, and reduce postoperative complications. Normally, to achieve weight reductions a nutritional treatment is prescribed, but the effects of exercise on these patients have been little studied.
Objectives: To know the effects of an exercise program on body composition and cardiovascular risk factors in patients awaiting BS.
Methods: Twenty-three patients awaiting BS were divided into two groups: a) an experimental group (EG, n = 12); b) a control group (CG, n = 11). Both groups received the usual care prior to surgery, but the EG also performed a 12-week exercise program in which endurance and resistance training were combined. Body composition, anthropometric measures, cardiovascular risk factors, physical fitness, basal metabolic rate and quality of life were assessed at baseline and at the end of the study.
详细描述
Patients included in the presurgical protocol for BS at two University Hospitals were recruited while awaiting surgery. Each patient participated in an initial interview, during which all the aspects of the program were carefully explained, and a written informed consent was obtained. After that, the individual's medical history was checked looking for the presence of the following exclusion criteria: a) cardiovascular diseases; b) severe functional limitations; c) chronic respiratory diseases; or d) being undergoing another exercise program at the time of the study. Finally, twenty-three participants were diachronically enrolled in the intervention at 3 to 6 months before the expected date of surgery. The patients were assigned to the experimental group (EG) or to the control group (CG) in chronological order of recruitment: the first 12 patients were included in the EG, and the other 11 patients in the CG. The study protocol was approved by the local ethics committee and conformed to the Declaration of Helsinki.
Both groups followed the usual presurgical care of their respective hospitals (psychological and nutritional counseling). In addition, the EG performed a 12-week monitored and supervised CEP, while the CG only received advice to follow an active lifestyle. Both groups were assessed at the start (T1) and the end of the study, after 12 weeks (T2). At each assessment session, body composition, anthropometric measures, physical fitness, cardiovascular risk (CVR) and CVR factors, basal metabolic rate (BMR) and health-related quality of life were measured in a laboratory under controlled conditions (temperature 22-24º; relative air humidity 45-60%). Blood samples from each patient were taken and analyzed in their respective hospitals at the same timepoints.
Concurrent exercise program (CEP) The CEP was divided into three 4-week blocks, for a total duration of 12 weeks. In the first-block endurance training (ET) (performed on a cycle-ergometer, arm-ergometer, elliptical and treadmill) and resistance training (RT) (performed in resistance machines for 5 muscle groups: hamstrings, pectorals, quadriceps, latissimus dorsi, and gastrocnemius) were combined in the same session. During the second-block, patients performed 3 sessions per week. One day, only ET was performed. In the other 2 sessions, patients performed a High Intensity Interval Training (HIIT) on a cycle ergometer or an arm-ergometer followed by 7 resistance exercises (biceps and triceps brachii were added to the previous 5 major muscle groups trained).
In the third-block, patients trained 4 days a week. Two days a week, HIIT and RT were combined in the same session. RT was performed after HIIT. It consisted in training 4 different major muscle groups in each session (pectorals, quadriceps, biceps, and hamstrings in the first session, and latissimus dorsi, triceps, gastrocnemius and deltoids in the second session). In the other two sessions, only ET was carried out. In all the blocks, 2 days a week of flexibility training were carried out.
The intensity of the ET was monitored using a heart rate (HR) monitor (FT40, Polar, Finland), while the intensity of the RT was determined by percentages of 1 maximum repetition, which was estimated using the Brzycki formula.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Sequential
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 35 Years 至 57 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Be on the surgery waiting list.
- •Follow the doctor's usual health prescriptions
排除标准
- •cardiovascular diseases
- •severe functional limitations
- •chronic respiratory diseases
- •being undergoing another exercise program at the time of the study
研究组 & 干预措施
Physical activity program
Before 3 to 6 months before the expected date of surgery, the experimental group, performed a 12-week monitored and supervised concurrent exercise program. Before and after of this period, body composition, anthropometric measures, physical fitness, cardiovascular risk, blood samples, Basal Metabolic Rate and health-related quality of life were measured in a laboratory under controlled conditions.
干预措施: Physical activity program (Other)
Habitual care prescription
Before 3 to 6 months before the expected date of surgery, the control group, followed the habitual care prescriptions until the surgery
结局指标
主要结局
Change from Baseline Cardiorespiratory Fitness at 3 months
时间窗: Baseline and 3 months, between 8:00 AM and 9:00 AM.
A protocol in cycle ergometer (Technogym Bike Med, Technogym, Gambettola, Italy) adapted Achten was used to determine the peak oxygen uptake (VO2peak) using an Oxycon Pro gas analysis system (Jaeger, Friedberg, Germany). This protocol consisted of two phases. In the first phase, patients performed a 4-minutes warm-up at 40 watts (W), followed by increases of 20 W every 3 minutes, maintaining a cadence of 60 rotations per minute (RPM), until the respiratory exchange ratio (RER) reached 1.0. At this point the second phase started, which consisted of increments of 20 w each minute, maintaining a cadence between 70-80 RPM, until volitional fatigue. The average of the highest 30 seconds of VO2 was used to calculate VO2peak. The VO2peak was expressed in absolute values (VO2peak abs) and normalized to total body weight (VO2peak/BW) and fat- free mass (VO2peak/FFM)
Change from Baseline Muscle strength at 3 months. Isometric strength measurement
时间窗: Baseline and 3 months, between 8:00 AM and 9:00 AM.
Dynamic and isometric strength of the quadriceps, hamstrings, biceps and triceps brachii were assessed using an isokinetic dynamometer (Biodex System 4; Biodex Medical Systems, New York, USA). Participants completed a submaximal repetition followed by 3 maximum voluntary contraction (15 s rest between repetitions), during which they were verbally encouraged to perform a maximal effort for 5 s, following the recommendations of previous research. The angles used for assessing quadriceps and hamstrings were of 105º and 75º, respectively, and triceps and biceps brachii were of 75º and 120º, respectively. As there was one set per exercise, the peak torque (N·m) was analyzed and normalized to the body weight (MISBW) and individual's FFM (MISFFM).
Change from Baseline Muscle strength at 3 months. Dynamic strength measurement
时间窗: Baseline and 3 months, between 8:00 AM and 9:00 AM.
Dynamic and isometric strength of the quadriceps, hamstrings, biceps and triceps brachii were assessed using an isokinetic dynamometer (Biodex System 4; Biodex Medical Systems, New York, USA). Participants performed 4 sets of 4 concentric contractions (flexion-extension) of the upper (elbow) and lower body (knee), at an angular speed of 60º/s, with 90 s rest between repetitions. The knee and elbow motion ranges were within 105° to 10° and within 160° to 60°, respectively. The first series was a submaximal familiarization trial. In the following three sets, participants were verbally encouraged to perform and maintain maximal effort in every contraction. The peak torque (N·m) of each set was analyzed and the average of the last three sets was calculated. Additionally, the peak torque was normalized to the individual's body weight (MDSBW) and relative to FFM (MDSFFM)
Change from Baseline Cardiovascular risk factors at 3 months.
时间窗: Baseline and 3 months, in a different day of the other tests, between 8:00 AM and 9:00 AM.
Blood samples were taken at the University Hospitals, after 12 hours overnight fast. Patients were instructed not to perform exercise 48 hours before the test. Standard methods were used to measure total cholesterol (TC), HDL cholesterol (HDL-C), glucose, HbA1C, and triglycerides (TG). Friedwald equation was used for calculating LDL cholesterol (LDL-C). Blood pressure was measured according to established recommendations, using a digital sphygmomanometer (Microlife WatchBP Home, Heerbrugg, Switzerland). Framingham cardiac risk score adapted to the Spanish context was used to calculate CVR. This formula, uses the TC, HDL-C, blood pressure values, sex, age, diabetic and/or smoking status, to calculate the 10-year coronary risk. In some subjects of the CG, this formula could not be applied, since they were less than 35 years old, thus, CVR was also determined by the waist-to-hip ratio (WHpR) (45) and by the waist-to-height ratio (WHtR)
Change from Baseline waist and hip circumference at 3 months
时间窗: Baseline and 3 months, between 7:30 AM and 8:30 AM.
The ISAK (International Society for the Advancement of Kinanthropometry) protocol was used to assess waist and hip circumference.
Change from Baseline Body Composition at 3 months
时间窗: Baseline and 3 months, between 7:30 AM and 8:30 AM.
Body mass index (BMI) was calculated according to the formula: total weight in kilograms divided by squared height in meters (kg·m-2). Participants performed the assessment with an empty bladder. Bioimpedance analysis (Tanita BC-420MA, Tanita, Tokyo, Japan) was used to establish body weight and body composition.
次要结局
- Change from Baseline Basal metabolic rate at 3 months(Baseline and 3 months, in a different day of the other tests, between 8:00 AM and 9:00 AM.)
- Change from Baseline Health-related quality of life at 3 months(Baseline and 3 months, between 8:00 AM and 9:00 AM.)
研究者
Manuel Moya
Principal Investigator
Universidad Miguel Hernandez de Elche