Differences in gene expression profile between Glucocorticoid-responsive and Glucocorticoid-nonresponsive patients with rheumatoid arthritis

Completed

• Conditions: rheumatism; 10018424; rheumatoid arthritis; 10003816; 10005959

• Registration Number: NL-OMON35438
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 80

Inclusion Criteria

Clinical indication for Glucocorticoid therapy either in high dose (Cohort A) or low dose (Cohort B) based on the judgement of the treating/attending physician according to clinical practice in our outpatient clinic.

Exclusion Criteria

1) Clinical contrandications for GC-therapy as handled in our outpatient clinic
2) Change of (DMARD) medication in the last month
3) GC treatment in the last month in both cohorts.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>A list of markers seen in monocytes and T cells that are differently expressed<br /><br>in GC-responders versus GC nonresponders. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>A list of markers seen in monocytes and T cells that are differently expressed<br /><br>in patients experiencing side effects and patients without side effects.</p><br>